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>   home   >   Products   >   Primary Antibodies   >   Anti-Connexin 43 (pSer368) Antibody    

Anti-Connexin 43 (pSer368) Antibody

Rabbit Anti-Rat Polyclonal Antibody

  • WB - Anti-Connexin 43 (pSer368) Antibody  ABD11515
    Western blot of rat hippocampal lysate showing phosphospecific immunolabeling of the ~43 kDa Connexin43 protein phosphorylated at Ser368
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08050
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 43031 Da
Additional Information
Purification Antisera to rat connexin43 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Immunogen Synthetic phosphopeptide corresponding to an amino acid sequence within connexin43 which includes phosphorylated Ser368
Shelf Life 12 months from date of reconstitution.
Gene ID 24392
Other Names Gap junction alpha-1 protein, Connexin-43, Cx43, Gap junction 43 kDa heart protein, Gja1, Cxn-43
Target/Specificity ABD11515 specifically recognises 43kDa Connexin43, when phosphorylated at Ser368. Connexin43 (CX43) allows for the exchange of solutions between neighbouring cells through the formation of gap-junctional channels and is expressed in the brain, kidneys and myocardium, as well as vascular endothelial cells. Studies suggest that a decrease in the permeability of gap-junctional channels occurs due to a conformational change in the structure of CX43, and that this is mediated by the phosphorylation of CX43 at residue Ser368, by Protein Kinase C (PKC). A possible link between CX43 and epilepsy has been investigated following the detection of high levels of CX43 in both low-grade tumours and peritumoural reactive astrocytes, see Aronica, E. et al. for details.
Preservative & Stabilisers 0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Connexin 43 (pSer368) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Bao, X. et al. (2004) Mechanism of regulation of the gap junction protein connexin 43 by protein kinase C-mediated phosphorylation.
Am. J. Physiol. Cell Physiol. 286: C647-C654.2. Bao, X. et al. (2004) Regulation of purified and reconstituted connexin 43 hemichannels by Protein Kinase C-mediated phosphorylation of Serine 368*.
J. Biol. Chem. 279: 20058-20066.3. Aronica, E. et al. (2001) Expression of connexin 43 and connexin 32 gap-junction proteins in epilepsy-associated brain tumors and in the perilesional epileptic cortex.
Acta. Neuropathol. (Berl). 101: 449-459.

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Cat# ABD11515
(40 western blots)
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