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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Amyotrophic Lateral Sclerosis (ALS)   >   Anti-NMDA Receptor NR2B (pTyr1336) Antibody    

Anti-NMDA Receptor NR2B (pTyr1336) Antibody

Rabbit Anti-Rat Polyclonal Antibody

  • WB - Anti-NMDA Receptor NR2B (pTyr1336) Antibody  ABD11516
    Western blot of rat hippocampal lysate showing phosphospecific immunolabeling of the ~180 kDa NR2B subunit of the NMDR phosphorylated at Tyr1336
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q00960
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 166071 Da
Additional Information
Purification Antisera to rat NMDA receptor NR2B subunit were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Immunogen Synthetic phosphopeptide corresponding to an amino acid sequence within the NR2B subunit of the NMDA receptor, which includes phosphorylated Tyr1336.
Shelf Life 12 months from date of reconstitution.
Gene ID 24410
Other Names Glutamate receptor ionotropic, NMDA 2B, GluN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B, Grin2b
Target/Specificity ABD11516 specifically recognises the 180kDa NR2B subunit of the NMDA (N-methyl-D-aspartate) receptor when phosphorylated at Tyr1336.Receptors for NMDA belong to a group of ionotropic glutamate receptors which play a key role in the mediation of glutamate neurotransmission within the mammalian central nervous system (CNS), including involvement in memory and learning processes. Several antagonists and agonists of NMDA receptors (NMDAR) have been identified, including the glutamate analogue Homoquinolinic acid, which displays a higher affinity for NR2B-containing NMDAR. Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage-dependent Mg2+ blockade and high Ca2+ permeability and the phosphorylation of Tyr1336 is thought to potentiate NMDAR-dependent Ca2+influx.The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer’s disease (Popke, E.J. 2003) and also epilepsy and ischemic neuronal cell death.
Preservative & Stabilisers 0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-NMDA Receptor NR2B (pTyr1336) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Takasu, M.A. et al. (2002) Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors.
Science. 295: 491-495. 2. Rosenblum, K. et al. (1996) Long-term potentiation increases tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor subunit 2B in rat dentate gyrus in vivo.
P.N.A.S USA. 93: 10457-10460.1. Ishii, T. et al. (1993) Molecular characterization of the family of the N-Methyl-D-Aspartate receptor subunits.
J. Biol. Chem. 268: 2836-2843.2. Popke, E.J. (2003) From anticholinesterase toxicity to Alzheimer’s disease: Important interactions of cholinergic and NMDA receptor systems.
Toxological Sciences 72: 185-187.

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Cat# ABD11516
(40 western blots)
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