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Anti-Human Dopamine beta Hydroxylase (C-Terminal) Antibody

Sheep Anti-Human Polyclonal Antibody

  • WB - Anti-Human Dopamine beta Hydroxylase (C-Terminal) Antibody  ABD11517
    Western blot of 2μg of human adrenal medulla lysate showing specific immunolabeling of the ~75 kDa DBH protein
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P09172
Reactivity Human
Host Sheep
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 69065 Da
Additional Information
Other Species M,Pr
Purification Antisera to human Dopamine Beta-Hydroxylase (CT) were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen Synthetic peptide corresponding to the C-terminal region of human Dopamine Beta-Hydroxylase, conjugated to KLH.
Shelf Life 12 months from date of reconstitution.
Gene ID 1621
Other Names Dopamine beta-hydroxylase,, Dopamine beta-monooxygenase, Soluble dopamine beta-hydroxylase, DBH
Target/Specificity Sheep anti-Human Dopamine beta hydroxylase recognizes an epitope within the C-terminal region (CT) of Dopamine Beta-Hydroxylase (DBH). DBH is a member of the copper type II, ascorbate-dependent monooxygenase family, which catalyzes the conversion of dopamine to norepinephrine, a key neurotransmitter in the central and peripheral nervous systems.The effects of DBH plasma levels have been a focus area for both neurological and psychiatric disorders, including Parkinson’s disease, hypertension, depression, schizophrenia, drug abuse and stress (Cubells and Zabetian 2004).
Preservative & Stabilisers 0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Dopamine beta Hydroxylase (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Cubells, J.F and Zabetian, C.P. (2004) Human genetics of plasma dopamine beta-hydroxylase activity: applications to research in psychiatry and neurology.
Physchopharm. (Berl). 174: 463-476.2. Kish, S.J. et al. (2001) Striatal dopaminergic and serotonergic markers in human heroin users.
Neuropsychopharm. 24: 561-567.3. Abe, M. et al. (2005) Association of dopamine B-hydroxylase polymorphism with hypertension through interaction with fasting plasma glucose in Japanese.
Hypertens. Res. 28: 215-221.4. Sabban, E.L. and Kvetnansky, R. (2001) Stress-triggered activation of gene expression in catecholaminergic systems: dynamics of transcriptional events.
Trends Neurosci. 24: 91-98.

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Cat# ABD11517
(40 western blots)
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