|Calculated MW||51754 Da|
|Purification||Antisera to rat GABAA receptor (NT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Keyhole limpet haemocyanin conjugated synthetic peptide corresponding to the N-terminal region of rat GABAA receptor Alpha-1 subunit.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Gamma-aminobutyric acid receptor subunit alpha-1, GABA(A) receptor subunit alpha-1, Gabra1, Gabra-1|
|Target/Specificity||Rabbit anti-GABA A Receptor alpha 1 antibody recognizes an epitope within the N-terminal region (NT) of the alpha 1 subunit of rat gamma-aminobutyric acid (A) (GABAA) receptor. GABAA receptors are GABA gated chloride channels, which are important mediators of neuronal inhibition in the mammalian central nervous system. Activation of the GABAA site results in increased intracellular chloride concentration and hyperpolarization of the cell. GABAA receptors are pentameric structures assembled from a family of distinct subunits. At least fourteen subunits have been identified, showing distinct patterns of temporal and spatial expression.GABAA receptors may be modulated by several drug types including benzodiazepines and barbiturates, and by phosphorylation by protein kinase C (PKC) and protein kinase A (PKA).|
|Preservative & Stabilisers||0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-GABA A Receptor alpha 1 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
1. Hausrat, T.J. et al. (2015) Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.Nat Commun. 6: 6872.1. Burt, D.R. and Kamatchi, G.L. (1991) GABAA receptor subtypes: from pharmacology to molecular biology.FASEB J. 5: 2916-2923.2. Olsen, R.W. and Tobin, A.J. (1990) Molecular biology of GABAA receptors.FASEB J. 4: 1469-1480.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.