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Anti-GABA A Receptor alpha 1 (N-Terminal) Antibody

Rabbit Anti-Rat Polyclonal Antibody

  • WB - Anti-GABA A Receptor alpha 1 (N-Terminal) Antibody  ABD11518
    Western blot of 5μg of mouse cerebellum lysates from wild type (control) and alpha 1 knockout (alpha 1 K/O) animals showing specific immunoblotting of the ~51 kDa alpha 1 subunit of the GABA alpha-R in the wild type but not in the alpha 1 K/O animals
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P62813
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 51754 Da
Additional Information
Other Species M
Purification Antisera to rat GABAA receptor (NT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen Keyhole limpet haemocyanin conjugated synthetic peptide corresponding to the N-terminal region of rat GABAA receptor Alpha-1 subunit.
Shelf Life 12 months from date of reconstitution.
Gene ID 29705
Other Names Gamma-aminobutyric acid receptor subunit alpha-1, GABA(A) receptor subunit alpha-1, Gabra1, Gabra-1
Target/Specificity Rabbit anti-GABA A Receptor alpha 1 antibody recognizes an epitope within the N-terminal region (NT) of the alpha 1 subunit of rat gamma-aminobutyric acid (A) (GABAA) receptor. GABAA receptors are GABA gated chloride channels, which are important mediators of neuronal inhibition in the mammalian central nervous system. Activation of the GABAA site results in increased intracellular chloride concentration and hyperpolarization of the cell. GABAA receptors are pentameric structures assembled from a family of distinct subunits. At least fourteen subunits have been identified, showing distinct patterns of temporal and spatial expression.GABAA receptors may be modulated by several drug types including benzodiazepines and barbiturates, and by phosphorylation by protein kinase C (PKC) and protein kinase A (PKA).
Preservative & Stabilisers 0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-GABA A Receptor alpha 1 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Hausrat, T.J. et al. (2015) Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.
Nat Commun. 6: 6872.1. Burt, D.R. and Kamatchi, G.L. (1991) GABAA receptor subtypes: from pharmacology to molecular biology.
FASEB J. 5: 2916-2923.2. Olsen, R.W. and Tobin, A.J. (1990) Molecular biology of GABAA receptors.
FASEB J. 4: 1469-1480.

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Cat# ABD11518
(40 western blots)
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