|Application ||IHC-F, FC|
|Calculated MW||38066 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Concanavilin A activated Canine T cells.|
|Shelf Life||18 months from date of despatch.|
|Other Names||CD44 antigen, Extracellular matrix receptor-III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I, CD44, CD44|
|Target/Specificity||Rat anti-Dog CD44 antibody, clone YKIX337.8.7 recognises canine CD44, also known as H-CAM, a single-pass type 1 membrane of approximately 90kDa expressed by most leucocytes and epithelial cells. CD44 expression is markedly increased upon cell activation (Alldingeret al.2000).CD44 is involved in cell-cell, cell adhesion and cell migration and is the principal cellular receptor for hyaluronate via it'sLINK domain, additionally CD44 also interacts with other ligands including collagens and metalloproteinases. Studies have demonstrated that altered CD44 expression is detected in a many forms of invasive and metasic cancers, CD44 expression has been observed on canine mammary and melanocytic tumours (Serraet al.2004).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Dog CD44 Antibody, clone YKIX337.8.7 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Cobbold, S. and Metcalfe, S. (1994) Monoclonal antibodies that define canine homologues of human CD antigens: summary of the first International Canine Leucocyte Antigen Workshop (CLAW).Tissue Antigens 43: 137-154. 2. Stein, V.M. et al. (2008) Immunophenotypical characterization of monocytes in canine distemper virus infection.Vet Microbiol. 131:237-46. 3. Salvatierra, A. et al. (2001) Antithrombin III prevents early pulmonary dysfunction after lung transplantation in the dog.Circulation. 104: 2975-80. 4. Sanchez, M.A. et al. (2004) Organ-specific immunity in canine visceral leishmaniasis: analysis of symptomatic and asymptomatic dogs naturally infected with Leishmania chagasi.Am J Trop Med Hyg. 70: 618-24. 5. Stein, V.M. et al. (2004) Characterization of canine microglial cells isolated ex vivo.Vet Immunol Immunopathol. 99: 73-85. 6. Heinrich Franziska et al. (2015) Immunophenotyping of immune cell populations in the raccoon (Procyon lotor)Veterinary Immunology and Immunopathology. Nov 3 [Epub ahead of print]
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