|Application ||WB, IHC-F, IP|
|Calculated MW||81545 Da|
|Purification||Tissue Culture Supernatant containing 0.2M Tris/HCl pH7.4 and 5-10% foetal calf serum|
|Immunogen||Baculovirus expressed (Recombinant) bovine p85 beta subunit of PI-3 kinase.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Phosphatidylinositol 3-kinase regulatory subunit beta, PI3-kinase regulatory subunit beta, PI3K regulatory subunit beta, PtdIns-3-kinase regulatory subunit beta, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta, PI3-kinase subunit p85-beta, PtdIns-3-kinase regulatory subunit p85-beta, PIK3R2|
|Target/Specificity||Mouse anti-PI-3 Kinase p85 Subunit beta antibody, clone T4 recognizes the p85 beta subunit of bovine PI-3 kinase, also known as Phosphatidylinositol 3-kinase regulatory subunit beta or Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta. The p85 beta subunit of bovine PI-3 kinase is a 724 amino acid ~85kDa protein containing a Rho-GAP domain, two SH2 domains and a single SH3domain.Mutations in the human PIK3R2 gene can lead to Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (Rivièreet al.2012).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-PI-3 Kinase p85 Subunit beta Antibody, clone T4 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Reif. K. et al. (1993) Divergent regulation of phosphatidylinositol 3-Kinase P85 alpha and P85 beta isoforms upon T cell activation.J. Biol. Chem. 278:10780-10788. 2. Shepherd, P.R. et al. (1997) Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle.J Biol Chem. 272: 19000-7.
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