|Application ||FC, IP|
|Calculated MW||25243 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Mouse T lymphoma EL-4 cells.|
|Shelf Life||18 months from date of despatch.|
|Other Names||T-cell-specific surface glycoprotein CD28, CD28, Cd28|
|Target/Specificity||Hamster anti-Mouse CD28 antibody, clone 37.51.1 recognizes murine CD28, an 80kDa cell surface glycoprotein that is expressed by most thymocyte subsets and by peripheral T-cells. Studies show that CD28 expression on thymocytes and splenic T-cells can be upregulated upon activation.Murine CD28 acts as a co-stimulatory signal and may play an important role in regulating the immune response of T-cells.Hamster anti-Mouse CD28 antibody, clone 37.51.1 has been reported to enhance cytokine production and T-cell proliferation in combination with TCR-mediated signals (Grosset al.1992).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD28 Antibody, clone 37.51.1 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Kawasaki, H. et al. (1999) Increased c-Fos/activator protein-1 confers resistance against induction on antigen-specific T cell. Int. Immnol. 11: 1873 - 1880. 2. Gross, G.A. et al. (1992) Identification and distribution of the co-stimulatory receptor CD28 in the mouse. J. Immunol. 149: 380 - 388.
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