|Application ||FC, IP|
|Calculated MW||25243 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Mouse T lymphoma EL-4 cells.|
|Shelf Life||18 months from date of despatch.|
|Other Names||T-cell-specific surface glycoprotein CD28, CD28, Cd28|
|Target/Specificity||Hamster anti-Mouse CD28 antibody, clone 37.51.1 recognizes murine CD28, an 80kDa cell surface glycoprotein that is expressed by most thymocyte subsets and by peripheral T-cells. Studies show that CD28 expression on thymocytes and splenic T-cells can be upregulated upon activation.Murine CD28 acts as a co-stimulatory signal and may play an important role in regulating the immune response of T-cells.Hamster anti-Mouse CD28 antibody, clone 37.51.1 has been reported to enhance cytokine production and T-cell proliferation in combination with TCR-mediated signals (Grosset al.1992).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD28 Antibody, clone 37.51.1 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Kawasaki, H. et al. (1999) Increased c-Fos/activator protein-1 confers resistance against induction on antigen-specific T cell. Int. Immnol. 11: 1873 - 1880. 2. Gross, G.A. et al. (1992) Identification and distribution of the co-stimulatory receptor CD28 in the mouse. J. Immunol. 149: 380 - 388.
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