|Application ||WB, IHC-F, FC, E|
|Calculated MW||17492 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.|
|Immunogen||Purified CHO cell expressed recombinant human IL-4.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interleukin-4, IL-4, B-cell stimulatory factor 1, BSF-1, Binetrakin, Lymphocyte stimulatory factor 1, Pitrakinra, IL4|
|Target/Specificity||Rat anti-Human Interleukin-4 antibody, clone MP4-25D2 recognizes human Interleukin-4 (IL-4), also known as B-cell stimulatory factor 1, Binetrakin, Pitrakinra or Lymphocyte stimulatory factor 1. Interleukin-4 is a 153 amino acid ~17kDa cytokine involved in the activation of B cells, macrophages and monocytes (UniProt: P05112).Polymorphisms in the IL-4 gene are asociated with susceptibility to, and outcome of ischemic stroke (Marousiet al.2011).Rat anti-Human Interleukin-4 antibody, clone MP4-25D2 is reported to neutralize IL-4 activity (Abramset al.1992andCarvalhoet al.1994).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Interleukin-4 Antibody, clone MP4-25D2 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Krohn, A. et al. (1998) Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector.J. Neurosci. 18: 8186-8197. 2. Kubota, M. et al. (1997) Oral immunization with Simian Immunodeficiency Virus p55 gag and cholera toxin elicits both mucosal IgA and systemic IgG immune responses in non human primates. J. Immunol. 158: 5321-5329. 2. Abrams, J. S. et al. (1992) Strategies of anti-cytokine monoclonal antibody development : Immunoassay of IL-10 and IL-5 in clinical samples.Immunol. Rev. 127: 5-24. 3. Patterson, B. et al. (2001) Leukemia inhibitory factor inhibits HIV-1 replication and is upregulated in placentae from nontransmitting women.J. Clin. Invest. 107: 287-294. 5. Carvalho, E. et al. (1994) Restoration of IFN-gamma production and lymphocyte proliferation in visceral leishmaniasis.J. Immunol. 152: 5949-5956.
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