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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   Anti-Sheep Interleukin-6 Antibody, clone 4B6    

Anti-Sheep Interleukin-6 Antibody, clone 4B6

Mouse Anti-Sheep Monoclonal Antibody

  • E - Anti-Sheep Interleukin-6 Antibody, clone 4B6  ABD11609
    Published customer image:Mouse anti Sheep Interleukin-6 antibody, clone 4B6 used as a capture antibody for the measurement of IL-6 levels in sheep plasma by ELISA.Image caption:Comparison of plasma concentrations of (A) IL-10 and (B) IL-6 measured over time in arthritic sheep treated and untreated with mesenchymal precursor cells (MPC). Each point represents the mean ± SEM of 7–8 sheep.**** Indicates a statistically significant difference between groups at that time point, p = 0.0001.From: Dooley LM, Abdalmula A, Washington EA, Kaufman C, Tudor EM, Ghosh P, et al. Effect of Mesenchymal Precursor Cells on the Systemic Inflammatory Response and Endothelial Dysfunction in an Ovine Model of Collagen-Induced Arthritis.PLoS ONE 10: e0124144.
  • E - Anti-Sheep Interleukin-6 Antibody, clone 4B6  ABD11609
    Published customer image:Mouse anti Sheep interleukin 6 antibody, clone 4B6 used as a capture reagent for the measurement of interleukin 6 in an ELISA using lamb sera.Image caption:Systemic and diaphragm cytokine responses. Plasma IL-1ß (A) and IL-6 (B) protein content. Values are mean ± SEM. Diaphragm IL-1ß (C) and IL-6 (D) mRNA expression. Values are median (with 10th and 90th centiles). * p
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P29455
Reactivity Sheep
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 4B6
Calculated MW 23446 Da
Additional Information
Other Species Pr
Immunogen Recombinant ovine IL-6.
Shelf Life 18 months from date of despatch.
Gene ID 443406
Other Names Interleukin-6, IL-6, IL6
Target/Specificity Mouse anti-Sheep Interleukin-6 antibody, clone 4B6 recognizes ovine interleukin-6 (IL-6) and has also been reported to recognise recombinant human IL-6 and bovine IL-6 transfected cells.Mouse anti-Sheep Interleukin-6 antibody, clone 4B6 does not cross react with ovine IL-1 beta, IL-8, MCP-1 or TNF alpha.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Sheep Interleukin-6 Antibody, clone 4B6 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. McWaters, P. et al. (2000) Characterisation of monoclonal antibodies to ovine interleukin-6 and the development of a sensitive capture ELISA.
Vet. Immunol. Immunopathol. 73: 155-165. 2. Wang, Z. et al. (2008) Acute hypercapnia improves indices of tissue oxygenation more than dobutamine in septic shock.
Am J Respir Crit Care Med. 177: 178-83. 3. Su, F. et al (2007) Beneficial effects of ethyl pyruvate in septic shock from peritonitis.
Arch Surg.142: 166-71. 4. Kabaroff, L. et al. (2006) Changes in ovine maternal temperature, and serum cortisol and interleukin-6 concentrations after challenge with Escherichia coli lipopolysaccharide during pregnancy and early lactation.
J Anim Sci. 84: 2083-8. 5. Shashikant, B.N. et al. (2005) Dose response to rhCC10-augmented surfactant therapy in a lamb model of infant respiratory distress syndrome: physiological, inflammatory, and kinetic profiles.
J Appl Physiol. 99: 2204-11. 6. Redondo, E. et al. (2014) Induction of interleukin-8 and interleukin-12 in neonatal ovine lung following experimental inoculation of bovine respiratory syncytial virus.
J Comp Pathol. 150 (4): 434-48. 7. Karisnan, K .et al. (2015) Interleukin-1 Receptor Antagonist Protects against Lipopolysaccharide Induced Diaphragm Weakness in Preterm Lambs.
PLoS One. 10 (4): e0124390. 8. Xu, A. et al. (2015) The Ovine Fetal and Placental Inflammatory Response to Umbilical Cord Occlusions With Worsening Acidosis.
Reprod Sci. pii: 1933719115580994. 9. Dooley, L.M. et al. (2015) Effect of mesenchymal precursor cells on the systemic inflammatory response and endothelial dysfunction in an ovine model of collagen-induced arthritis.
PLoS One. 10 (5): e0124144.

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Cat# ABD11609
(40 western blots)
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