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Mouse Anti-Chicken Monoclonal Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| IHC-P, IHC-F |
|---|---|
| Primary Accession | P50890 |
| Reactivity | Chicken |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone Names | 2G13 |
| Calculated MW | 33021 Da |
| Other Species | Rat,M |
|---|---|
| Immunogen | Embryonic chick tectal membranes. |
| Shelf Life | 18 months from date of despatch. |
| Gene ID | 395181 |
| Other Names | 40S ribosomal protein SA {ECO:0000255|HAMAP-Rule:MF_03016}, 37 kDa laminin receptor precursor {ECO:0000255|HAMAP-Rule:MF_03016}, 37LRP {ECO:0000255|HAMAP-Rule:MF_03016}, 37/67 kDa laminin receptor {ECO:0000255|HAMAP-Rule:MF_03016}, LRP/LR {ECO:0000255|HAMAP-Rule:MF_03016}, 67 kDa laminin receptor {ECO:0000255|HAMAP-Rule:MF_03016}, 67LR {ECO:0000255|HAMAP-Rule:MF_03016}, Laminin receptor 1 {ECO:0000255|HAMAP-Rule:MF_03016}, LamR {ECO:0000255|HAMAP-Rule:MF_03016}, Laminin-binding protein precursor p40 {ECO:0000255|HAMAP-Rule:MF_03016}, LBP/p40 {ECO:0000255|HAMAP-Rule:MF_03016}, RPSA {ECO:0000255|HAMAP-Rule:MF_03016}, LAMR1 |
| Target/Specificity | Mouse anti-Growth Cone antibody, clone 2G13 recognizes a protein originally termed 2G13P which is localized to growth cones. Subsequent investigation has identified this protein to be 40S ribosomal protein SA, also known as 37 kDa laminin receptor precursor or Laminin receptor 1 (Balouiet al.2004). 40S ribosomal protein SA is a 296 amino acid ~37kDa membrane, cytoplasmic and nuclear protein required for the assembly and/or stability of the 40S ribosomal subunit.. In vertebrate evolution the molecule has acquired a secondary function as a laminin receptor (UniProt: P50890). In growth cones expression is notable particularly in filopodia and lamellipodia in developing rat CNS and embryonic neurons in culture (Stettleret al.1999).40S ribosomal protein SA interacts with the filamentous actin cytoskeleton and therefore may be involved in growth cone motility (Stettleret al.1999). Mouse anti-Growth Cone antibody, clone 2G13 has been used for the detection of growth cones by immunohistochemistry and identification of 40S ribosomal protein SA by western blotting in chicken and rat samples (Balouiet al.2004). |
| Preservative & Stabilisers | 0.09% Sodium Azide |
| Storage | Store at +4℃ or at -20 ℃. |
| Precautions | Anti-Growth Cone Antibody, clone 2G13 is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
References
1. Stettler, O. et al. (1999) Monoclonal antibody 2G13, a new axonal growth cone marker.J. Neurocytol. 28: 1035 - 1044. 2. Baloui, H. et al. (2004) Cellular prion protein/laminin receptor: distribution in adult central nervous system and characterization of an isoform associated with a subtype of cortical neurons.Eur. J. Neurosci. 20(10): 2605-2616. 3. Espejo, C. et al. (2005) Time-course expression of CNS inflammatory, neurodegenerative tissue repair markers and metallothioneins during experimental autoimmune encephalomyelitis.Neuroscience. 132(4):1135-49. 4. Kim, S.R. et al. (2011) Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration.Ann Neurol. 70: 110-20.
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