|Application ||WB, FC, IP|
|Calculated MW||23722 Da|
|Other Species||Cynomolgus Pr,Rh|
|Purification||Purified IgG prepared from ascites|
|Immunogen||Normal human T lymphocytes|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||T-cell surface glycoprotein CD8 beta chain, CD8b, CD8B, CD8B1|
|Target/Specificity||Mouse anti-Human CD8 beta antibody, clone 2ST8.5H7 recognizes the human CD8 cell surface antigen. The antibody binds to the beta chain, recognising an epitope that is dependent upon expression of both CD8 alpha and CD8 beta.CD8 molecules are composed of dimers of either alpha/alpha or alpha/beta polypeptide combinations. Both types of dimer may co-exist at the cell surface.|
|Preservative & Stabilisers||1% Bovine Serum Albumin;|
|Storage||Storage at 4℃ or at -20℃.|
|Precautions||Anti-Human CD8 Beta Antibody, clone 2ST8.5H7 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Terry, L.A. et al. (1990) Differential expression and regulation of the human CD8 alpha and CD8 beta chains.Tissue Antigens 35: 82-91. 2. DiSanto, J.P. et al. (1991) Generation of anti-human CD8 beta specific antibodies using transfectants expressing mixed species CD8 heterodimers. J. Immunol. Methods 141: 123-131. 3. de la Calle-Martin, O. et al. (2001) Familial CD8 deficiency due to a mutation in the CD8 alpha gene.J Clin Invest. 108: 117-23. 4. Fry, T.J. et al. (2002) IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primates.Blood. 101: 2294-9. 5. Schmitz, J.E. et al (1998) Expression of the CD8alpha beta-heterodimer on CD8(+) T lymphocytes in peripheral blood lymphocytes of human immunodeficiency virus- and human immunodeficiency virus+ individuals.Blood. 92: 198-206.
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