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>   home   >   Products   >   Primary Antibodies   >   Anti-Dog CD11d Antibody, clone CA11.8H2    

Anti-Dog CD11d Antibody, clone CA11.8H2

Mouse Anti-Dog Monoclonal Antibody

  • FC - Anti-Dog CD11d Antibody, clone CA11.8H2  ABD11635
    Staining of canine peripheral blood lymphocytes with Mouse anti Dog CD11d:Alexa Fluor® 647
  • FC - Anti-Dog CD11d Antibody, clone CA11.8H2  ABD11635
    Staining of canine peripheral blood lymphocytes with Mouse anti Dog CD11d followed by Goat anti Mouse IgG (H/L):FITC
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Dog
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names CA11.8H2
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Affinity purified CD11 antigen from canine spleen.
Shelf Life 18 months from date of despatch.
Target/Specificity Mouse anti-Dog CD11d antibody, clone CA11.8H2 recognizes the canine CD11d cell surface antigen, also known as integrin alpha d subunit.The alpha d integrin (CD11d) subunit is expressed as a heterodimer with beta 2 integrin (CD18). CD11d is expressed by a sub-population of macrophages, some CD8 positive T cells and by gamma/delta T cells in the splenic red pulp.Over expression of CD11d is noted in histiocytic disorders including hemophagocytic sarcoma, described as a proliferative disorder specifically of CD11+ macrophages ( al.2006) with macrophages demonstrating marked erythrocytic phagocytosis. Previously, canine histiocytic sarcoma were described as originating entirely from interstitial dendritic cells. Cells from animals with canine hepatosplenic T cell lymphoma (HTSL) strongly express CD11d on malignant cells. Dogs normally demonstrate strong positivity for CD11d on large granular lymphocytes, macrophages and T cells in the splenic red pulp. CD11+ γ/δ T cells constitute ~30% red pulp T cells despite their rarity in peripheral blood, suggesting a splenic red pulp origin of HTSL (Fryet al.2003).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Dog CD11d Antibody, clone CA11.8H2 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Danilenko, D.M. et al. (1995) A novel canine leukointegrin, alpha d beta 2, is expressed by specific macrophage subpopulations in tissue and a minor CD8+ lymphocyte subpopulation in peripheral blood.
J Immunol. 155:35-44. 2. Moore, P.F. et al. (2006) Canine hemophagocytic histiocytic sarcoma: a proliferative disorder of CD11d+ macrophages.
Vet Pathol. 43:632-45. 3. Vernau, W. and Moore, P.F. (1999) An immunophenotypic study of canine leukemias and preliminary assessment of clonality by polymerase chain reaction.
Vet Immunol Immunopathol. 69:145-64. 4. Fry, M.M. et al. (2003) Hepatosplenic lymphoma in a dog.
Vet Pathol. 40:556-62. 5. Stokol, T. et al. (2015) Alkaline phosphatase is a useful cytochemical marker for the diagnosis of acute myelomonocytic and monocytic leukemia in the dog.
Vet Clin Pathol. 44 (1): 79-93.1. Vernau. W. (2004) Flow Cytometric Assessment of Hematopoietic Neoplasia in the Dog.
In:55th Annual Meeting of the American College of Veterinary Pathologists (ACVP) & 39th Annual Meeting of the American Society of Clinical Pathology (ASVCP),

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Cat# ABD11635
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