|Application ||WB, IHC-P, IHC-F, IF|
|Calculated MW||32520 Da|
|Immunogen||Recombinant human cyclin D3.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||G1/S-specific cyclin-D3, CCND3|
|Target/Specificity||Mouse anti-Human Cyclin D3 antibody, clone DCS-22 recognizes human G1/S-specific cyclin-D3, also known as CCND3. Cyclin D3 is a 292 amino acid ~34kDa regulatory protein affecting the cell cycle during the G1/S transition. Cyclin D3 is expressed in the G1 phase of the cell cycle, but after cyclin D1.Mouse anti-Human Cyclin D3 antibody, clone DCS-22 has been used for the detection od cyclin D3 in canine tissues using immunofluorescence and western blotting (Depoortereet al.1998).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Storage at 4℃ or at -20℃.|
|Precautions||Anti-Human Cyclin D3 Antibody, clone DCS-22 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Bartkova, J. et al. (1996) Abundance and subcellular localisation of cyclin D3 in human tumours.Int. J. Cancer 65: 323-327. 2. Pertia, A. et al. (2009) Immunoreactivity of p27(Kip1), cyclin D3, and Ki67 in conventional renal cell carcinoma.Int Urol Nephrol. 41: 243-9. 3. Nikoleishvili, D. et al. (2008) Expression of p27((Kip1)), cyclin D3 and Ki67 in BPH, prostate cancer andhormone-treated prostate cancer cells. Int Urol Nephrol. 40: 953-9. 4. Giddabasappa, A. et al. (2011) Low-level gestational lead exposure increases retinal progenitor cell proliferation and rod photoreceptor and bipolar cell neurogenesis in mice.Environ Health Perspect. 119:71-7. 5. Ott, M.M. et al. (1997) Cyclin D1 expression in mantle cell lymphoma is accompanied by downregulation of cyclin D3 and is not related to the proliferative activity.Blood. 90: 3154-9. 6. Depoortere, F. et al. (1998) A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes.J Cell Biol. 140: 1427-39. 7. Van Keymeulen, A. et al. (1999) Cyclin D3 accumulation and activity integrate and rank the comitogenic pathways of thyrotropin and insulin in thyrocytes in primary culture.Oncogene. 18: 7351-9.
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