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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human Cdk7 Antibody, clone MO-1    

Anti-Human Cdk7 Antibody, clone MO-1

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P50613
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names MO-1
Calculated MW 39038 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A/G
Immunogen 221 amino acid recombinant fragment of Cdk7 C terminus
Shelf Life 18 months from date of despatch.
Gene ID 1022
Other Names Cyclin-dependent kinase 7,,, 39 kDa protein kinase, p39 Mo15, CDK-activating kinase 1, Cell division protein kinase 7, Serine/threonine-protein kinase 1, TFIIH basal transcription factor complex kinase subunit, CDK7, CAK, CAK1, CDKN7, MO15, STK1
Target/Specificity Mouse anti-Human Cdk7 antibody, clone MO-1 recognizes human Cyclin-dependent kinase 7, also known as 39kDa protein kinase, Cell division protein kinase 7, Serine/threonine-protein kinase 1 and TFIIH basal transcription factor complex kinase subunit. Cdk7 is a 346 amino acid member of the CDC2/CDKX subfamily of serine/threonine family of protein kinases. Cdk7, as part of the CAK complex is involved with the transcription factor TFIIH and is thought to be involved in the control of cell cycle progression, DNA repair and RNA polymerase II (pol II) transcription.Cdk7 demonstrates ubiquitous muclear expression in normal tissues and is expressed in cancer tissues (Bartkovaet al.1996).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Cdk7 Antibody, clone MO-1 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Tassan, J.P. et al. (1994) Cell cycle analysis of the activity, subcellular localization and subunit composition of human CAK (CDK-activating kinase).
J. Cell. Biol. 127: 467-478. 2. Syljuåsen, R.G. et al. (2006) Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases.
Cancer Res. 66: 10253-7. 3. Falck, J. et al. (2001) Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.
Oncogene. 20: 5503-10.

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Cat# ABD11674
(40 western blots)
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