|Application ||WB, IHC-F, IP|
|Calculated MW||39038 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A/G|
|Immunogen||221 amino acid recombinant fragment of Cdk7 C terminus|
|Shelf Life||18 months from date of despatch.|
|Other Names||Cyclin-dependent kinase 7, 220.127.116.11, 18.104.22.168, 39 kDa protein kinase, p39 Mo15, CDK-activating kinase 1, Cell division protein kinase 7, Serine/threonine-protein kinase 1, TFIIH basal transcription factor complex kinase subunit, CDK7, CAK, CAK1, CDKN7, MO15, STK1|
|Target/Specificity||Mouse anti-Human Cdk7 antibody, clone MO-1 recognizes human Cyclin-dependent kinase 7, also known as 39kDa protein kinase, Cell division protein kinase 7, Serine/threonine-protein kinase 1 and TFIIH basal transcription factor complex kinase subunit. Cdk7 is a 346 amino acid member of the CDC2/CDKX subfamily of serine/threonine family of protein kinases. Cdk7, as part of the CAK complex is involved with the transcription factor TFIIH and is thought to be involved in the control of cell cycle progression, DNA repair and RNA polymerase II (pol II) transcription.Cdk7 demonstrates ubiquitous muclear expression in normal tissues and is expressed in cancer tissues (Bartkovaet al.1996).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Cdk7 Antibody, clone MO-1 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Tassan, J.P. et al. (1994) Cell cycle analysis of the activity, subcellular localization and subunit composition of human CAK (CDK-activating kinase).J. Cell. Biol. 127: 467-478. 2. Syljuåsen, R.G. et al. (2006) Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases.Cancer Res. 66: 10253-7. 3. Falck, J. et al. (2001) Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.Oncogene. 20: 5503-10.
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