|Application ||WB, IHC-P|
|Calculated MW||38224 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from ascites|
|Immunogen||Denatured bacterially expressed recombinant human HLA G heavy chain|
|Shelf Life||18 months from date of despatch.|
|Other Names||HLA class I histocompatibility antigen, alpha chain G, HLA G antigen, MHC class I antigen G, HLA-G, HLA-6.0, HLAG|
|Target/Specificity||Mouse anti-Human HLA G antibody, clone MEM-G/1 reacts with denatured soluble and membrane-bound HLA G heavy chain.The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In humans, this complex is referred to as the human leukocyte antigen (HLA) region.HLA G belongs to the HLA class I molecules (HLA Class Ib; nonclassical) and is involved in the presentation of foreign antigens to the immune system. This molecule is expressed on the surface of trophoblast cells and plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T lymphocytes, macrophages and mononuclear cells.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human HLA G Antibody, clone MEM-G/1 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Frumento, G. et al. (2000) Melanomas and melanoma cell lines do not express HLA-G, and the expression cannot be induced by gammaIFN treatment.Tissue Antigens 56: 30-37. 2. Fournel, S. et al. (2000) Comparative reactivity of different HLA-G monoclonal antibodies to soluble HLA-G molecules.Tissue Antigens 55: 510-518. 3. Menier, C. et al. (2003) Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: New tools to analyze the expression of nonclassical HLA class I molecules.Human Immunol. 64: 315-326. 4. Orozco, A.F. and Lewis, D.E. (2010) Flow cytometric analysis of circulating microparticles in plasma.Cytometry A. 77: 502-14. 5. Comiskey, M. et al. (2007) HLA-G is found in lipid rafts and can act as a signaling molecule.Hum Immunol. 68: 1-11. 6. Chang, C.T. et al. (2005) Immunophenotypic and molecular cytogenetic features of the cell line UP-LN1 established from a lymph node metastasis of a poorly-differentiated carcinoma.Anticancer Res. 25: 683-91.
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