|Application ||WB, IHC-F, IP|
|Calculated MW||347603 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G.|
|Immunogen||Recombinant protein corresponding to amino acids 2703 - 2911 of huntingtin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Huntingtin, Huntington disease protein, HD protein, HTT, HD, IT15|
|Target/Specificity||Mouse anti-Huntingtin antibody, clone HDC8A4 reacts with an epitope corresponding to the HDC region (2703 - 2911 amino acids) of the huntingtin protein.Mouse anti-Huntingtin antibody, clone HDC8A4 detects a 350KDa band on western blots but also detects smaller degradation products of huntingtin. Clone HDC8A4 recognises both denatured and native huntingtin in human brain. The combined use of Mouse anti-Huntingtin antibody, clone HDC8A4 (ABD11684), HDB4E10 (MCA2050) and HDA3E10 (MCA2049) demonstrate that huntingtin is enriched in neuronal cells in the brain.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Huntingtin Antibody, clone HDC8A4 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Wilkinson, F. L. et al. (1999) Localization of rabbit huntingtin using a new panel of monoclonal antibodies.Molecular Brain Research. 69: 10-20. 2. Yao Y et al. (2015) A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.Elife. 4: 4. 3. Jones, A.L. (1999) The localization and interactions of huntingtin.Philos Trans R Soc Lond B Biol Sci. 354 (1386): 1021-7. 4. Lazzeroni G et al. (2013) A phenotypic screening assay for modulators of huntingtin-induced transcriptional dysregulation.J Biomol Screen. 18 (9): 984-96. 5. Li X et al. (2008) A function of huntingtin in guanine nucleotide exchange on Rab11.Neuroreport. 19 (16): 1643-7.
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