|Application ||WB, IHC-P, E|
|Calculated MW||149715 Da|
|Immunogen||Denatured Human kidney CD143 (angiotensin converting enzyme).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Angiotensin-converting enzyme, ACE, 3.2.1.-, 126.96.36.199, Dipeptidyl carboxypeptidase I, Kininase II, CD143, Angiotensin-converting enzyme, soluble form, ACE, DCP, DCP1|
|Target/Specificity||Mouse anti-Human CD143 antibody, clone 2E2 recognizes human CD143, also know as angiotensin - converting enzyme (ACE). CD143 exists in two forms, a 170 kDa somatic form and a 90 kDa germinal form. The somatic form is expressed by endothelial cells (especially those of lung capillaries and arterioles), epithelial cells (especially in proximal renal tubules and small intestine), by some neuronal cells and variably by some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa. Study of CD143 may be relevant to fertility (especially sperm-egg interactions), atherosclerosis and in drug targeting to the lung. This clone recognises denatured somatic form of ACE, binding to an epitope in the C domain, and has been reported to be active in western blotting (Balyasnikovaet al.2003). Mouse anti-Human CD143 antibody, clone 2E2 was produced in the same fusion as clone 3C5 (ABD11688) which recognizes both the somatic and germinal denatured forms of CD143.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD143 Antibody, clone 2E2 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Metzger, R. et al. (1999) Angiotensin-converting enzyme in non-neoplastic kidney diseases.Kidney Int. 56 (4): 1442-54. 2. Balyasnikova, I.V. et al. (2003) Monoclonal antibodies to denatured ACE (CD143) broad species specificity, reactivity on paraffin sections and detection of subtle conformational changes in the C-terminal domain of ACE. Tissue Antigens. 61 (1): 49- 62.
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