|Application ||WB, IHC-P, IHC-F, E|
|Calculated MW||28526 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Synthetic peptide corresponding to amino acids 249-269 of aquaporin 1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Aquaporin-1, AQP-1, Aquaporin-CHIP, Urine water channel, Water channel protein for red blood cells and kidney proximal tubule, AQP1, CHIP28|
|Target/Specificity||Clone 1/A5F6 recognizes an epitope within the cytoplasmic domain of the water-specific channel aquaporin 1 (also known as AQP1 or CHIP-28).Aquaporin 1 is a 28kD integral membrane protein which was originally identified in red blood cells and the kidney. AQP1 is also expressed by the choroid plexus and various other tissues. The glycosylated forms of AQP1 range between 40-60kD in mass.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Aquaporin 1 Antibody, clone 1/A5F6 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Nagy, G. et al. (2002) Development and characterisation of a monoclonal antibody family againstaquaporin 1 (AQP1) and aquaporin 4 (AQP4).Pathol. Oncol. Res. 8: 115-124. 2. Bodis, B. et al. (2001) Active water selective channels in the stomach: investigation of aquaporins after ethanol and capsaicin treatment in rats. J. Physiol. 95: 271-275. 3. Francone, V.P. et al (2010) Signaling from the secretory granule to the nucleus: Uhmk1 and PAM.Mol Endocrinol. 24: 1543-58. 4. Felszeghy, S. et al (2004) Expression of aquaporin isoforms during human and mouse tooth development.Arch Oral Biol. 49: 247-57. 5. Ripoche, P. et al. (2004) Human Rhesus-associated glycoprotein mediates facilitated transport of NH(3) into red blood cells.Proc Natl Acad Sci U S A. 101: 17222-7. 6. Lupp, A. et al. (2010) Immunohistochemical identification of the PTHR1 parathyroid hormone receptor in normal and neoplastic human tissues.Eur J Endocrinol. 162: 979-86. 7. Pannabecker, T.L. et al. (2008) Quantitative analysis of functional reconstructions reveals lateral and axial zonation in the renal inner medulla.Am J Physiol Renal Physiol. 294: F1306-14. 8. Thiele, S. et al. (2007) A disruptive mutation in exon 3 of the GNAS gene with albright hereditary osteodystrophy, normocalcemic pseudohypoparathyroidism, and selective long transcript variant Gsalpha-L deficiency.J Clin Endocrinol Metab. 92: 1764-8. 9. Antonelou, M.H. et al. (2011) Oxidative stress-associated shape transformation and membrane proteome remodeling in erythrocytes of end stage renal disease patients on hemodialysis.J Proteomics. 74: 2441-52. 10. Arnaud, L. et al. (2010) A functional AQP1 allele producing a Co(a-b-) phenotype revises and extends the Colton blood group system.Transfusion. 50: 2106-16. 11. Saison, C. et al. (2012) A new AQP1 null allele identified in a Gypsy woman who developed an anti-CO3 during her first pregnancy.Vox Sang. 103: 137-44.
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