|Application ||WB, IHC-F|
|Calculated MW||106159 Da|
|Other Species||H,M,Eastern Newt (Notophthalmus viridescens)|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Synthetic peptide C-ADMYLSPLRSPK phosphorylated at S608, conugated to KLH.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110, RB1|
|Target/Specificity||Mouse anti-retinoblastoma gene protein (pSer608), clone 51B7 recognizes human and mouse Rb protein only when it has been phosphorylated at the S608 residue.Mouse anti-retinoblastoma gene protein (pSer608), clone 51B7 does not recognize non-phosphorylated Rb or Rb phosphorylated at other sites.Phosphorylation of the Rb protein at S608 is dependent upon CDK4 (Zarkowska and Mittnacht 1997).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Retinoblastoma Gene Protein (pSer608) Antibody, clone 51B7 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Barrie, S. et al. (2003) High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells.Anal. Biochem. 320:66-74. 2. Bettencourt-Dias, M. et al. (2003) Heterogeneous proliferative potential in regenerative adult newt cardiomyocytes.J Cell Sci. 116: 4001-9.
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