|Application ||IHC-P, IHC-F|
|Calculated MW||70255 Da|
|Immunogen||Extract of pigmented melanoma metastases from lymph nodes.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Melanocyte protein PMEL, ME20-M, ME20M, Melanocyte protein Pmel 17, Melanocytes lineage-specific antigen GP100, Melanoma-associated ME20 antigen, P1, P100, Premelanosome protein, Silver locus protein homolog, M-alpha, 95 kDa melanocyte-specific secreted glycoprotein, P26, Secreted melanoma-associated ME20 antigen, ME20-S, ME20S, M-beta, PMEL, D12S53E, PMEL17, SILV|
|Target/Specificity||Mouse anti-Human HMB45 antibody, clone HMB-45 recognizes the HMB-45 antigen, an intracytoplasmic antigen expressed by the majority of melanomas and with other tumors demonstrating melanocytic differentiation. tumors of lymphoid, epithelial, glial and mesenchymal origin are negative.Normal adult melanocytes do not label with this antibody, although fetal and neonatal melanocytes stain variably.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human HMB45 Antibody, clone HMB-45 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Racchi, C.E. et al. (1996) HMB-45. A review.Applied Immunohistochemistry. 4: 73-85. 2. Clements, D. et Al. (2009) Analysis of the oestrogen response in an angiomyolipoma derived xenograft model.Endocr Relat Cancer. 16: 59-72. 3. Ginger, R.S. et al. (2008) SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis.J Biol Chem. 283: 5486-95. 4. Fonsatti, E. et al. (2007) Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications.Clin Cancer Res. 13: 3333-8.
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