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Anti-Human HMB45 Antibody, clone HMB-45

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P40967
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names HMB-45
Calculated MW 70255 Da
Additional Information
Immunogen Extract of pigmented melanoma metastases from lymph nodes.
Shelf Life 18 months from date of despatch.
Gene ID 6490
Other Names Melanocyte protein PMEL, ME20-M, ME20M, Melanocyte protein Pmel 17, Melanocytes lineage-specific antigen GP100, Melanoma-associated ME20 antigen, P1, P100, Premelanosome protein, Silver locus protein homolog, M-alpha, 95 kDa melanocyte-specific secreted glycoprotein, P26, Secreted melanoma-associated ME20 antigen, ME20-S, ME20S, M-beta, PMEL, D12S53E, PMEL17, SILV
Target/Specificity Mouse anti-Human HMB45 antibody, clone HMB-45 recognizes the HMB-45 antigen, an intracytoplasmic antigen expressed by the majority of melanomas and with other tumors demonstrating melanocytic differentiation. tumors of lymphoid, epithelial, glial and mesenchymal origin are negative.Normal adult melanocytes do not label with this antibody, although fetal and neonatal melanocytes stain variably.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human HMB45 Antibody, clone HMB-45 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Racchi, C.E. et al. (1996) HMB-45. A review.
Applied Immunohistochemistry. 4: 73-85. 2. Clements, D. et Al. (2009) Analysis of the oestrogen response in an angiomyolipoma derived xenograft model.
Endocr Relat Cancer. 16: 59-72. 3. Ginger, R.S. et al. (2008) SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis.
J Biol Chem. 283: 5486-95. 4. Fonsatti, E. et al. (2007) Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications.
Clin Cancer Res. 13: 3333-8.

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Cat# ABD11711
(40 western blots)
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