|Calculated MW||89838 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.|
|Immunogen||CHO cell line transfected with human TLR2 (CD282).|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4, CD282, TLR2, TIL4|
|Target/Specificity||Mouse anti-Human CD282 antibody, clone TL2.3 recognizes human TLR2, otherwise known as CD282. TLR2 is a member of the Toll-like receptor (TLR) family and is expressed primarily by peripheral blood monocytes.TLRs are expressed on the cell surface and the endocytic compartment and recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents.They also initiate cell signalling to induce production of cytokines necessary for the innate immunity and subsequent adaptive immunity. TLR2 is reported to respond to a diverse range of bacterial cell wall components, mediating the innate immune response in co-operation with MD-2.Mouse anti-Human CD282 antibody, clone TL2.1 is reported to block TLR2 function.|
|Preservative & Stabilisers||0.09% Sodium azide; 1% Bovine Serum Albumin; 5% Sucrose|
|Storage||Storage at +4ºC. DO NOT FREEZE.|
|Precautions||Anti-Human CD282 Antibody, clone TLR2.3 (RPE) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Lien, E. et al. (1999) Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.J Biol Chem. 274 (47): 33419-25. 2. Flo, T.H. et al. (2001) Differential expression of Toll-like receptor 2 in human cells.J Leukoc Biol. 69 (3): 474-81. 3. Sels, J.W. et al. (2012) Fractional flow reserve is not associated with inflammatory markers in patients with stable coronary artery disease.PLoS One. 7 (10): e46356.
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