Cartilage Oligomeric Matrix Protein Antibody, clone MA37C94 (HC484D1) (Monoclonal Antibody)
Rat Anti-Human Monoclonal Antibody
|Application ||WB, IHC-P, IHC-F, E, IP|
|Clone Names||MA37C94 (HC484D1)|
|Calculated MW||82860 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Human cartilage derived COMP.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Cartilage oligomeric matrix protein, COMP, Thrombospondin-5, TSP5, COMP|
|Target/Specificity||Rat anti-Human cartilage oligomeric matrix protein, antibody, clone MA37C94 recognies human cartilage oligomeric matrix protein (COMP), otherwize known as Thrombospondin-5 (TSP-5). COMP is a 757 amino acid ~:100 kDa matrix glycoprotein bearing four EGF-like domains, a single TSP C-terminal do,aim and eight TSP type-3 repeats (Uniprot P49747). Defects in the COMP gene can lead to the presence of Pseudoachondroplasia (Poseyet al.2014) or Multiple epiphyseal dysplasia (http://www.ncbi.nlm.nih.gov/pubmed/152666134).Rat anti-Human cartilage oligomeric matrix protein antibody, clone at anti-Human cartilage oligomeric matrix protein, clone MA37C94 recognizes an epitope located in the central portion of the molecule.Rat anti-Human cartilage oligomeric matrix protein, antibody, clone MA37C94 has been described as suitable for use in western blotting (Gagarinaet al.2008) and immunohistochemistry (Grigoriadiset al.2006)|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Cartilage Oligomeric Matrix Protein Antibody, clone MA37C94 (HC484D1) (Monoclonal Antibody) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Grigoriadis, A.et al. (2006) Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data.Breast Cancer Res. 8: R56. 2. Milz, S. et al. (2007) An immunohistochemical study of the triangular fibrocartilage complex of the wrist: regional variations in cartilage phenotype.J Anat. 211: 1-7. 3. Gagarina, V. et al. (2008) Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins. J Biol Chem 283: 648-59. 4. Jäger, M. et al. (2006) Ovine cord blood accommodates multipotent mesenchymal progenitor cells.In Vivo. 20: 205-14.
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