|Application ||WB, IP|
|Calculated MW||59609 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Shelf Life||18 months from date of despatch.|
|Other Names||T-complex protein 1 subunit theta, TCP-1-theta, CCT-theta, CCT8|
|Target/Specificity||Rat anti-CCT theta antibody, clone PK/13/72/8k recognises the theta polypeptide of the CCT chaperonin molecule complex, also known as T-complex protein 1 subunit theta, CCT8 or CCTθ, a 547 amino acid ~:60kDa molecular chaperone.The intact CCT complex is composed of eight polypeptides in a double-ring structure. CCT is important within cells in aiding the folding of proteins including actin, tubulin and the VHL tumour suppressor protein.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-CCT Theta Antibody, clone PK/13/72/8k is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Hynes, G. et al. (1996) Analysis of chaperonin-containing TCP-1 subunits in the human keratinocytetwo-dimensional protein database: further characterisation of antibodies toindividual subunits.Electrophoresis. 17: 1720-1727. 2. Llorca, O. et al. (2000) Eukaryotic chaperonin CCT stabilizes actin and tubulin folding intermediates inopen quasi-native conformations. EMBO J. 19: 5971-5979. 3. Hynes, G.M. Willison, K.R. (2000) Individual subunits of the eukaryotic cytosolic chaperonin mediate interactionswith binding sites located on subdomains of beta-actin.J Biol Chem. 275: 18985-18994. 4. Plimpton, R.L. et al. (2015) Structures of the Gβ-CCT and PhLP1-G&beta-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ? dimer assembly.Proc Natl Acad Sci U S A. 112 (8): 2413-8.
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