Anti-Sheep MHC Class II DQ DR Polymorphic Antibody, clone 28.1 (RPE)
Mouse Anti-Sheep Monoclonal Antibody
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Ovine alveolar macrophages.|
|Shelf Life||12 months from date of reconstitution.|
|Target/Specificity||Mouse anti-Sheep MHC Class II DQ DR antibody, clone 28.1 recognizes a polymorphic epitope on ovine MHC class II DQ and DR molecules, which are constitutively expressed on antigen presenting cells such as dendritic cells, B lymphocytes, monocytes, macrophages, activated T lymphocytes and may be induced on a range of other cell types by interferon gamma.The major histocompatibility complex (MHC) is a cluster of genes some of which are important in the immune response to infections. In sheep, this complex is referred to as the ovine leukocyte antigen (OLA) region. There are 2 major types of MHC class IIa molecules encoded by the OLA which are DR and DQ each composed of an alpha and beta chain. Mouse anti-Sheep MHC Class II DQ DR antibody, clone 28.1 recognises ovine MHC II transfectants DQ - T28.1, DQ - T26.2 and DR - T31.3 but not DR - T8.1. (Ballingall, K. et al. 1995).|
|Preservative & Stabilisers||0.09% Sodium azide; Stabilising agent|
|Storage||Storage at +4ºC. DO NOT FREEZE.|
|Precautions||Anti-Sheep MHC Class II DQ DR Polymorphic Antibody, clone 28.1 (RPE) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Puri, N. et al. (1985) Sheep lymphocyte antigens (OLA) II. Major histocompatibility complex class II molecules. Immunology. 56: 725 - 733. 2. Puri, N. et al. (1987) Monoclonal antibodies to sheep MHC class I and class II molecules: biochemical characterization of three class I gene products and four distinct subpopulations of class II molecules. Vet. Immunol. Immunopathol. 15: 59 - 86. 3. Puri, N. et al. (1987) Sheep MHC class II molecules. I. Immunochemical characterization. Immunology. 62: 567 - 573. 4. Puri, N. et al. (1987) Sheep MHC class II molecules. II. Identification and characterization of four distinct subsets of sheep MHC class II molecule. Immunology. 62: 575 - 580. 5. Puri, N. et al. (1987) Monoclonal antibodies to sheep MHC class II molecules recognize all HLA-D or subsets of HLA-D region products. Hum. Immunol. 20: 195 - 207. 6. Ferret-Bernard, S. et al. (2011) Mesenteric lymph node cells from neonates present a prominent IL-12 response to CpG oligodeoxynucleotide via an IL-15 feedback loop of amplification.Vet Res. 42:19. 7. Olivier, M. et al. (2012) Capacities of Migrating CD1b Lymph Dendritic Cells to Present Salmonella Antigens to Naive T Cells.PLoS One. 7: e30430. 7. Ballingall. K. et al. (1995) Analysis of the fine specificities of sheep major histocompatibility complex class II - Specific monoclonal antibodies using mouse L - Cell transfectants.Anim. Genet. 26: 79-84.
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