|Calculated MW||39692 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Porcine peripheral blood mononuclear cells.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Membrane cofactor protein, CD46, CD46, MCP|
|Target/Specificity||Mouse anti-Pig CD46 antibody, clone JM6C11 recognizes porcine CD46, also known as membrane cofactor protein (MCP). CD46 is a ~45-65 kDa single pass type 1 transmembrane glycoprotein expressed by all peripheral blood cells.Mouse anti-Pig CD46 antibody, clone JM6C11 inhibits functional MCP cofactor activity as measured by inhibition of cleavage of the α chain of C3 (Pérez De La Lastra et al.1999).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Pig CD46 Antibody, clone JM6C11 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. van den Berg, C.W. et al. (1997) Purification and characterization of the pig analogue of human membrane cofactor protein (CD46/MCP).J Immunol. 158: 1703-9. 2. Haverson, K. et al. (2001) Overview of the Third International Workshop on Swine Leukocyte Differentiation Antigens.Vet Immunol Immunopathol. 80: 5-23. 3. Pérez De La Lastra, J.M. et al. (1999) Epitope mapping of 10 monoclonal antibodies against the pig analogue of human membrane cofactor protein (MCP).Immunology. 96: 663-70. 4. Dräger, C. et al. (2015) Porcine complement regulatory protein CD46 and heparan sulfates are the major factors for classical swine fever virus attachment in vitro.Arch Virol. 160 (3): 739-46.1. Piriou-Guzylack, L. (2008) Membrane markers of the immune cells in swine: an update.Vet Res. 39: 54.
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