|Application ||WB, IP|
|Calculated MW||60449 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Shelf Life||18 months from date of despatch.|
|Other Names||T-complex protein 1 subunit alpha, TCP-1-alpha, CCT-alpha, Tailless complex polypeptide 1A, TCP-1-A, Tailless complex polypeptide 1B, TCP-1-B, Tcp1, Cct1, Ccta|
|Target/Specificity||Rat anti-CCTα antibody, clone 91a recognises the alpha polypeptide of the CCT chaperonin molecule complex.The intact CCT complex is composed of eight polypeptides in a double-ring structure. CCT is important within cells in aiding the folding of proteins including actin, tubulin and the VHL tumour suppressor protein.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-CCT alpha Antibody, clone 91a is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Liou, A.K. and Willison, K.R. (1997) Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes.EMBO J. 16: 4311-6. 2. Hynes, G.M. and Willison, K.R. (2000) Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin.J Biol Chem. 275: 18985-94. 3. Satish L et al. (2011) Chaperonin containing T-complex polypeptide (CCT) subunit expression in oral mucosal wounds and fibroblasts.Cell Stress Chaperones. 16 (6): 675-80. 4. Tracy CM et al. (2014) Programmed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate ß-tubulin folding.J Biol Chem. 289 (7): 4490-502. 5. Plimpton, R.L. et al. (2015) Structures of the Gβ-CCT and PhLP1-Gßβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly.Proc Natl Acad Sci U S A. 112 (8): 2413-8.
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