|Application ||WB, IF, E|
|Calculated MW||39336 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Synthetic peptide corresponding to 18 C terminal amino acids of human CD88, phosphorylated at Serine 332, 334 and 338.|
|Shelf Life||18 months from date of despatch.|
|Other Names||C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR, CD88, C5AR1, C5AR, C5R1|
|Target/Specificity||ABD11752 recognises the human CD88 cell surface antigen (also known as C5a receptor), following phosphorylation at the Serine 334 epitope.Phosphorylation of Ser-334 by ligand binding is required for internalization of this receptor and stimulation of chemotaxis, see Braun, L. et al. for details.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD88 (pSer334) Antibody, clone 32-G1 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Braun, L. et al. (2003) Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway.J. Biol. Chem. 278:4277-4285.
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