|Calculated MW||21919 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||A20 mouse B cell lymphoma cell line|
|Shelf Life||18 months from date of despatch.|
|Other Names||CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7, CD70, Cd70, Cd27l, Cd27lg, Tnfsf7|
|Target/Specificity||Rat anti-Mouse CD70 antibody, clone FR70 recognizes mouse CD70, a 30-33kD type II transmembrane protein belonging to the TNF superfamily. CD70 is not expressed on resting T and B lymphocytes but expression is induced on activation. Interaction of CD70 with its ligand CD27 is reported to play an important role in T-cell co-stimulation and the regulation of T-dependant B-cell activation and antibody production.Clone FR70 is reported to block the functions of CD70 and has been used to block the interactions between CD27 and CD70 (Oshimaet al.).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 1% Bovine Serum Albumin|
|Storage||Store at +4℃ or -20℃.|
|Precautions||Anti-Mouse CD70 Antibody, clone FR70 (FITC) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Oshima, H. et al. (1998) Characterization of murine CD70 by molecular cloning and mAb.Int. Immunol.10:517 – 526. 2. Takeda, K. et al. (2000) CD27-Mediated Activation of Murine NK Cells.J. Immunol.164:1741-1745. 3. Akiba, H. et al. (2000) Critical Contribution of OX40 Ligand to T Helper Cell Type 2 Differentiation in Experimental Leishmaniasis.J. Exp. Med.191:375-380. 4. Akiba, H. et al. (1999) CD28-Independent Costimulation of T Cells by OX40 Ligand and CD70 on Activated B Cells.J. Immunol.162:7058 – 7066. 5. Hadziahmetovic, M. et al. (2012) Microarray Analysis of Murine Retinal Light Damage Reveals Changes in Iron Regulatory, Complement, and Antioxidant Genes in the Neurosensory Retina and Isolated RPE.Invest Ophthalmol Vis Sci. 53: 5231-41.
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