|Calculated MW||109276 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Cells from cattle intestine.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Aminopeptidase N, AP-N, bAPN, 22.214.171.124, Alanyl aminopeptidase, Aminopeptidase M, AP-M, Microsomal aminopeptidase, CD13, ANPEP, APN|
|Target/Specificity||Mouse anti-bovine CD13, clone CC81, recognises bovine CD13, a 150 kD type II membrane protein shown to be a metallopeptidase in humans. In cattle the antigen recognised by clone CC81 is primarily expressed on enterocytes and cells with a dendritic morphology in the small intestine. Clone CC81 also defines a subpopulation of dendritic cells in afferent lymph that are CC81 Ag +ve and SIRPalpha -ve, which show differences in their capacities to stimulate T cells and cytokine synthesis compared to the CC81 Ag –ve SIRPalpha +ve dendritic cells.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Bovine CD13 Antibody, clone CC81 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Howard, C.J. et al. (1997) Identification of two distinct populations of dendritic cells in afferent lymph that vary in their ability to stimulate T cells.J Immunol. 159 (11): 5372-82. 2. Hope, J.C. et al. (2001) Differences in the induction of CD8+ T cell responses by subpopulations of dendritic cells from afferent lymph are related to IL-1 alpha secretion.J Leukoc Biol. 69 (2): 271-9. 3. Stephens, S. A. et al. (2003) Differences in cytokine synthesis by the sub-populations of dendritic cells from afferent lymph.Immunology. 110: 48-57. 4. Bastos, R.G. et al. (2008) Bovine NK cells acquire cytotoxic activity and produce IFN-gamma after stimulation by Mycobacterium bovis BCG- or
Babesia bovis-exposed splenic dendritic cells.Vet Immunol Immunopathol. 124: 302-12.
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