|Calculated MW||37408 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Immunogen||Human lymph node tissue.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Macrosialin, Gp110, CD68, CD68|
|Target/Specificity||Mouse anti-Human CD68 antibody, clone Ki-M7 recognizes the 110KD integral membrane glycoprotein CD68 (Macrosialin) predominantly expressed on the intracellular lysosomes of macrophages/monocytes, including Kupffer cells, microglia, histiocytes and osteoclasts, and is expressed to a lesser extent by dendritic cells and peripheral blood granulocytes. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including Acute Myeloid Leukemia. In immunohistochemical studies, CD68 can be used to aid in the identification of blastic NK lymphomas, some B cell lymphomas, and to help diagnose disorders relating to macrophage abnormalities, including malignant histocytosis and Gaucher’s disease. Clone Ki-M7 has also been reported as being suitable for use in immunoprecipitation studies.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 1% Bovine Serum Albumin|
|Storage||Store at +4℃ or -20℃.|
|Precautions||Anti-Human CD68 Antibody, clone Ki-M7 (FITC) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Kreipe, H. et al. (1987) Ki-M7 Monoclonal Antibody Specific for Myelomonocytic Cell Lineage and Macrophages in Human.J. Histochem. Cytochem. 35: 1117-1126. 2. Diop, O.M. et al. (2000) High Levels of Viral Replication during Primary Simian Immunodeficiency Virus SIVagm Infection Are Rapidly and Strongly Controlled in African Green Monkeys.J. Virology 74: 7538-7547. 3. Micklem, K. et al. (1989) A human macrophage-associated antigen (CD68) detected by six different monoclonal antibodies. Brit. J. Haem 73: 6-11. 4. Bendelja, K. et al. (2010) Decreased Toll-like receptor 8 expression and lower TNF-alpha synthesis in infants with acute RSV infection.Respir Res. 11: 143. 5. Vergo, S. et al. (2011) Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model.Brain. 134: 571-584. 6. Karlsson, K.R. et al. (2008) Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3.Exp Hematol. 36: 1167-1175. 7. Gottfried, E. et al. (2008) Expression of CD68 in non-myeloid cell types.Scand J Immunol. 67: 453-63. 8. Sakakibara, S. et al. (2009) Gene regulation and functional alterations induced by Kaposi's sarcoma-associated herpesvirus-encoded ORFK13/vFLIP in endothelial cells.J Virol. 83: 2140-53.1. Sadovnikova, E. et al. (2002) The CD68 protein as a potential target for leukaemia-reactive CTL.Leukemia 16: 2019-2026.
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