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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-SLP-76 Antibody, clone SLP-76/03    

Anti-SLP-76 Antibody, clone SLP-76/03

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13094
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names SLP-76/03
Calculated MW 60188 Da
Additional Information
Other Species Pig,M
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen A fusion protein corresponding to amino acids 216-434 of human SLP-76.
Shelf Life 18 months from date of despatch.
Gene ID 3937
Other Names Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein, SLP76, LCP2
Target/Specificity Mouse anti-SLP-76 antibody, clone SLP-76/03 recognises the SH2 domain-containing leucocyte protein, also known as SLP-76 or Lymphocyte cytosolic protein 2. SLP-76 is a ~76 kDa tyrosine phosphoprotein, expressed primarily by T lymphocytes and cells of the myeloid lineage.SLP-76 is one of several adaptor proteins assisting with TCR-mediated signal transduction, through GRB2 binding, functioning as a substrate for the protein-tyrosine kinase ZAP-70 and thus playing a crucial role in both T cell ontogeny and activation. Other molecules that associate with SLP-76 include phospholipase C (PLC)–gamma, Vav, Nck and fyn binding protein.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-SLP-76 Antibody, clone SLP-76/03 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Di Bartolo V et al. (2007) A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.
J Exp Med. 204 (3): 681-91. 2. Brockmeyer, C. et al. (2011) T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies themis as a new TCR signalosome component.
J Biol Chem. 286: 7535-47. 3. Lasserre, R. et al. (2011) Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.
J Cell Biol. 195 (5): 839-53. 4. Lasserre, R. et al. (2010) Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.
EMBO J. 29: 2301-14. 5. Paster, W. et al. (2013) GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
J Immunol. 190 (7): 3749-56.1. Bonilla, F.A. et al. (2000) Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Fcgamma receptors I and II/III.
Proc Natl Acad Sci U S A. 97 (4): 1725-30.

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Cat# ABD11772
(40 western blots)
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