|Application ||WB, IHC-F, IP|
|Calculated MW||60762 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Immunogen||Bacterially expressed recombinant fragment of human fyn aa 7-176.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tyrosine-protein kinase Fyn, 188.8.131.52, Proto-oncogene Syn, Proto-oncogene c-Fyn, Src-like kinase, SLK, p59-Fyn, FYN|
|Target/Specificity||ABD11773 recognizes p59fyn (fyn), a 59kDa member of the src family of non receptor protein tyrosine kinases, expressed by T cells and Natural Killer (NK) cells and highly expressed in brain.Fyn plays a vital role in thymocyte development and T cell activation and is essential for TCR-mediated signal transduction through association with the T Cell Receptor (TCR) eta chain/CD3 Complex. This association, results in protein kinase activation and the subsequent protein tyrosine phosphorylation of multiple immunoreceptor tyrosine-based activation motifs (ITAMs), which triggers the phosphorylation of further substrates downstream in the T cell signaling cascade.Recent studies into Alzheimer’s Disease have implicated fyn in neurodegeneration, through the tyrosine phosphorylation of the microtubule-associated protein tau, a prominent component of neurofibrillary tangles.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-FYN Antibody, clone FYN-01 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Meraner, P. et al. (2007) Dendritic cells sensitize TCRs through self-MHC-mediated Src family kinase activation.J Immunol. 178:2262-71.1. Ho, G.J. et al. (2005) Altered p59Fyn kinase expression accompanies disease progression in Alzheimer’s disease: implications for its functional role.Neurobiol. Aging. 26: 625-35.2. Lee, G. et al. (2004) Phosphorylation of Tau by Fyn: Implications for Alzheimer’s disease.J. Neuroscience 24:2304-12.3. Olszowy, M.W. et al. (1995) Comparison of p56lck and p59fyn protein expression in thymocyte subsets, peripheral T cells, NK cells and lymphoid cell lines.J. Immunol. (1995). 155(9):4236-4240.4. Zamoyska, R. et al. (2003) The influence of the src-family kinases Lck and Fyn, on T cell differentiation, survival and activation.Immunol. Rev. 191:107-118.
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