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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human Lck Antibody, clone LCK-01    

Anti-Human Lck Antibody, clone LCK-01

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P06239
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names LCK-01
Calculated MW 58001 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Synthetic peptide corresponding to amino acids 22-36 of human lck.
Shelf Life 18 months from date of despatch.
Gene ID 3932
Other Names Tyrosine-protein kinase Lck,, Leukocyte C-terminal Src kinase, LSK, Lymphocyte cell-specific protein-tyrosine kinase, Protein YT16, Proto-oncogene Lck, T cell-specific protein-tyrosine kinase, p56-LCK, LCK
Target/Specificity Mouse anti-Human Lck antibody, clone Lck-01 recognizes Tyrosine-protein kinase Lck, also known as Lck, p56lck, Leukocyte C-terminal Src kinase, Lymphocyte cell-specific protein-tyrosine kinase, Protein YT16, Proto-oncogene Lck or T cell-specific protein-tyrosine kinase. Lck is a 508 amino acid ~56 kDa cytosolic non-receptor protein tyrosine kinase, primarily expressed in T lymphocytes and natural killer cells.Lck is a pivotal enzyme for normal T cell development and TCR-mediated signal transduction. Lck is physically associated with the cytoplasmic region of T cell specific molecules CD4 and CD8 (Bolen & Veillette 1989) and plays an important role in the phosphorylation of several proteins further downstream in the T cell signalling cascade (Veilletteet al.1988).Mutations of the Lck gene can lead to immunodeficiency 22 (IMD22), a condition characterized by T-cell dysfunction, patients presenting with recurrent infections, diarrhea and general malaise (Goldmanet al.1998).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Lck Antibody, clone LCK-01 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Romagnoli, P et al. (2001) A potential role for protein tyrosine kinase p56lck in rheumatoid arthritis synovial fluid T lymphocyte hyporesponsiveness.
Int. Immunol. 13(3):305-312. 2. Cebecauer, M. et al. (1998) Incorporation of leucocyte GPI-anchored proteins and protein tyrosine kinases into lipid-rich membrane domains of COS-7 cells.
Biochem. Biophys. Res. Commun. 243(3):706-710. 3. Kumar, S. et al. (2011) Disruption of HLA-DR raft, deregulations of Lck-ZAP-70-Cbl-b cross-talk and miR181a towards T cell hyporesponsiveness in leprosy.
Mol Immunol. 48 (9-10): 1178-90.

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Cat# ABD11774
(40 western blots)
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