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Anti-Human SOCS-3 Antibody, clone SO1

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O14543
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names SO1
Calculated MW 24770 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Immunogen Full - length SOCS3 protein.
Shelf Life 18 months from date of despatch.
Gene ID 9021
Other Names Suppressor of cytokine signaling 3, SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SSI-3, SOCS3, CIS3, SSI3
Target/Specificity Mouse anti-Human SOCS-3 antibody, clone SO1 recognizes the human suppressor of cytokine signaling 3 protein, also known as SOCS-3, cytokine-inducible SH2 protein 3 or STAT-induced STAT inhibitor 3. SOCS-3 is a 225 amino acid, 30kDa member of the suppressor of cytokine signaling family (Starret al.1997) containing a single SH2 and a single SOCS box domain. SOCS-3 acts as a negative regulator of Janus Kinase (JAK) and signal transducer and activators of transcription (STAT) signaling pathways.SOCS-3 specifically acts as a negative feedback regulator for the STAT3 pathways, by directly binding to the Tyr-759 motif of the IL-6 signal-transducing receptor subunit gp130, thereby preventing the IL-6 activation of STAT3. The expression of SOCS-3 is inducible by numerous factors, including IL-6, IL-10, Toll-like receptor (TLR) agonists and IFN gamma, making this protein the focus of research into inflammatory diseases, such as Arthritis, Colitis, and Crohn’s Disease (Elliott and Johnstone 2004). SOCS-3 expression has also been shown to affect IFN alpha sensitivity in tumour studies (Brender et al.2001).Notch signaling plays a critical role in the determination of M1 versus M2 macrophage polarization, and that RBPJ–mediated Notch signaling, regulates this polarization through SOCS-3 (Narayana and Balaji 2008,Schroeder and Just 2000).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human SOCS-3 Antibody, clone SO1 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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5. De Rosa, V. et al. (2007) A key role of leptin in the control of regulatory T cell proliferation.
Immunity. 26: 241-55.1. Lehmann, U. et al. (2003) SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130.
J Biol. Chem. 278(1): 661-671. 2. Suzuki, A. et al. (2001) CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation.
J. Exp. Med. 193(4): 471-481. 3. Lang, R. et al. (2003) SOCS3 regulates the plasticity of gp130 signaling.
Nature Immunology 4(6): 546-550. 4. Sakai, I. et al. (2002) Constitutive expression of SOCS3 confers resistance to IFN-alpha in chronic myelogenous leukemia cells.
Blood 100(8): 2926-2930.

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Cat# ABD11775
(40 western blots)
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