|Application ||WB, E|
|Calculated MW||22116 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Recombinant chicken Interferon alpha.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interferon type A1/A2, IFNA1|
|Target/Specificity||ABD11784 recognizes chicken Interferon alpha (chIFN-alpha). The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken. A growing number of functional studies indicate similarities between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Further research has shown that chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that recombinant chicken IFN acts as a potent antiviral agent. ABD11784 does not cross react with IFN beta or IFN gamma and does not neutralize chIFN-alpha.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Chicken Interferon alpha Antibody, clone UMCh3-IFNa is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Sarmento, L. et al. (2008) Differential host gene expression in cells infected with highly pathogenic H5N1 avianinfluenza viruses. Vet Immunol Immunopathol. 125: 291-302. 3. Schwarz, H. et al. (2004) Synthesis of IFN-beta by virus-infected chicken embryo cells demonstrated with specific antisera and a new bioassay.J. Interferon Cytokine Res. 24: 179-184. 1. Staeheli, P. et al. (2001) Cytokines of Birds: Conserved functions – A largely different look.J. Interferon Cytokine Res. 21: 993-1010.2. Sick, C et al. (1996) A family of genes coding for two serologically distinct chicken interferons. J. Biol. Chem. 271(13): 7635-7639.
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