|Application ||FC, E|
|Calculated MW||22724 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.|
|Immunogen||Recombinant mouse GITRL.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tumor necrosis factor ligand superfamily member 18, Activation-inducible TNF-related ligand, AITRL, Glucocorticoid-induced TNF-related ligand, hGITRL, TNFSF18, AITRL, GITRL, TL6|
|Target/Specificity||Rat anti-Mouse GITRL antibody, clone YGL386 recognizes mouse glucocorticoid-induced tumour necrosis factor receptor ligand (GITRL), a 20 kD member of the tumour necrosis factor ligand superfamily, otherwise known as TNSF18. Mouse GITRL is predominantly expressed on immature and mature dendritic cells, macrophages and B cells. Expression of mouse GITRL can be transiently up regulated on these cells, following lipolysaccharide (LPS) stimulation, but protein expression is rapidly down modulated shortly after stimulation.Studies demonstrate that GITRL can neutralise the suppressive effects of CD4+CD25+ regulatory T cells and can also provide a co-stimulatory signal for both naïve and primed T cells, suggesting a key role for GITRL in the regulation of T cell-mediated immunity.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse GITRL Antibody, clone YGL386 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Cobbold, S.P. et al. (2004) Induction of FoxP3+ Regulatory T Cells in the Periphery of T cell Receptor Transgenic mice Tolerized to Transplants. J Immunol.172:6003 - 6010. 2. Sakihama, T. et al. (2008) A simple detection method for low-affinity membrane protein interactions by baculoviral display.PLoS One. 3: e4024. 3. Tone, M. et al. (2003) Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells.Proc Natl Acad Sci U S A. 100:15059-64.
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