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Anti-Mouse CD86 Antibody, clone PO3

Rat Anti-Mouse Monoclonal Antibody

  • FC - Anti-Mouse CD86 Antibody, clone PO3  ABD11790
    Staining of LPS stimulated mouse spleen cells with Rat anti Mouse CD86:FITC
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P42082
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2b
Clone Names PO3
Calculated MW 34666 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Mouse B-cell line, BCL1.
Shelf Life 18 months from date of despatch.
Gene ID 12524
Other Names T-lymphocyte activation antigen CD86, Activation B7-2 antigen, Early T-cell costimulatory molecule 1, ETC-1, CD86, Cd86
Target/Specificity Rat anti-mouse CD86 recognizes mouse CD86 (B7-2), an 80kD cell surface glycoprotein which is a member of the CD28/B7 family. In mouse CD86 is expressed at high levels on peripheral blood monocytes and dendritic cells, and at low levels on resting B and T-lymphocytes. Expression of CD86, on these cell populations, can be increased upon activation.CD86 has been identified, along with CD80 (B7-1), as a ligand for CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA4). CD28 and CTLA4 are two receptors that have opposing functions in T-cell stimulation. Interaction of CD86 with CD28 promotes a number of T-cell activities, whereas the binding of CD86 to CTLA4 inhibits T-cell responses.The PO3 antibody has been reported to block some co-stimulatory functions of CD86  (Nakajimaet al.1997).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse CD86 Antibody, clone PO3 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Jin, J.P. et al. (2004) Adoptive transfer of paternal antigen-hyporesponsive T cells induces maternal tolerance to the allogeneic fetus in abortion-prone matings.
J. Immunol. 174: 3612-3619. 2. Nozawa, al. (2001) Preferential blockade of CD8+ T cell responses by administration of anti-CD137 ligand monoclonal antibody results in differential effect on development of murine acute and chronic graft-versus-host diseases.
J. Immunol. 167: 4981-4986. 3. Nakajima, A. et al. (1997) Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells.
Int. Immunol. 9: 637-644. 4. Bedoret, D. et al. (2009) Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice.
J. Clin. Invest. 119: 3723-3738. 5. Legutko, A. et al. (2011) Sirtuin 1 Promotes Th2 Responses and Airway Allergy by Repressing Peroxisome Proliferator-Activated Receptor-{gamma} Activity in Dendritic Cells.
J Immunol. 187: 4517-29.

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$ 56.00
Cat# ABD11790
1 Formats Available
Availability: 5-7days
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