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>   home   >   Products   >   Primary Antibodies   >   Anti-Epstein-Barr Virus LMP2A Antibody, clone 14B7    

Anti-Epstein-Barr Virus LMP2A Antibody, clone 14B7

Rat Anti-Viral Monoclonal Antibody

  • FC - Anti-Epstein-Barr Virus LMP2A Antibody, clone 14B7  ABD11791
    strong>Published customer image:Rat anti Epstein-Barr Virus LMP2A antibody, clone 14B7 used for the detection of EBNA-1 in cell extracts by western blotting.Image caption:(a) Epitope comparison amongst the variants and those observed in the 3 cell lines studied. Red letters denote amino acid mutation. (b) Quantitation of HLA-A0201/LMP1,/LMP2A and/EBNA1 on CCRF-SB, RPMI-6666 and C666-1A2 using TCR-like mAbs based on flow cytometry. Error bars are standard deviation from an average of three independent experiments. **p < 0.01. n.d. denotes not detectable. (c) LMP1, LMP2A and EBNA1 in each of the cell lines was determined using RT-PCR and Western blot. &beta;-actin was used as control.From: Sim AC, Too CT, Oo MZ, Lai J, Eio MY, Song Z, Srinivasan N, Tan DA, Pang SW, Gan SU, Lee KO, Loh TK, Chen J, Chan SH, MacAry PA. Defining the expression hierarchy of latent T-cell epitopes in Epstein-Barr virus infection with TCR-like antibodies.Sci Rep. 2013 Nov 18;3:3232.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Virus
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names 14B7
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Bacterial TrpE-LMP2A fusion protein
Shelf Life 18 months from date of despatch.
Target/Specificity Rat anti-Epstein-Barr Virus LMP2A antibody, clone 14B7 recognizes latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV). EBV is a human herpesvirus, which is associated with conditions such as Hodgkin’s disease and Burkitt’s Lymphoma and is the causative agent in mononucleosis in adolescents.EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.Clone 14B7 detects wild-type LMP2A protein.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Epstein-Barr Virus LMP2A Antibody, clone 14B7 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Fruehling, S. et al. (1996) Identification of latent membrane protein 2A (LMP2A) domains essential for the LMP2A dominant-negative effect on B-lymphocyte surface immunoglobulin signal transduction.
J Virol. 70:6216 – 6226. 2. Fruehling, S. et al. (1998) Tyrosine 112 of latent membrane protein 2A is essential for protein tyrosine kinase loading and regulation of Epstein-Barr virus latency.
J Virol. 72:7796 – 7806. 3. Ikeda, A. et al. (2003) Itchy, a Nedd4 ubiquitin ligase, downregulates latent membrane protein 2A activity in B-cell signaling.
J Virol. 77: 5529-34. 4. Longan, L. and Longnecker, R. (2000) Epstein-Barr virus latent membrane protein 2A has no growth-altering effects when expressed in differentiating epithelia.
J Gen Virol. 81: 2245-52. 5. Lynch, D.T. et al. (2002) Epstein-Barr virus latent membrane protein 2B (LMP2B) co-localizes with LMP2A in perinuclear regions in transiently transfected cells.
J Gen Virol. 83: 1025-35. 6. Bultema, R. et al. (2009) Epstein-Barr virus LMP2A accelerates MYC-induced lymphomagenesis.
Oncogene. 28: 1471-6. 7. Katzman, R.B. and Longnecker, R. (2004) LMP2A does not require palmitoylation to localize to buoyant complexes or for function.
J Virol. 78: 10878-87. 8. Anderson, L.J. and Longnecker, R. (2008) An auto-regulatory loop for EBV LMP2A involves activation of Notch.
Virology. 371: 257-66. 9. Merchant, M. et al. (2000) The LMP2A ITAM is essential for providing B cells with development and survival signals in vivo.
J Virol. 74: 9115-24. 10. Bieging, K.T. et al. (2009) Epstein-Barr virus LMP2A bypasses p53 inactivation in a MYC model of lymphomagenesis.
Proc Natl Acad Sci USA 106: 17945-50. 11. Caldwell, R.G. et al (2000) Epstein-Barr virus LMP2A-induced B-cell survival in two unique classes of EmuLMP2A transgenic mice.
J Virol. 74: 1101-13. 12. Moody, C.A. et al. (2005) Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A.
J Virol. 79: 5499-506. 13. Rovedo, M. and Longnecker, R. (2007) Epstein-barr virus latent membrane protein 2B (LMP2B) modulates LMP2A activity.
J Virol. 81: 84-94. 14. Sim, A.C. et al. (2013) Defining the expression hierarchy of latent T-cell epitopes in Epstein-Barr virus infection with TCR-like antibodies.
Sci Rep. 3: 3232.

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Cat# ABD11791
(40 western blots)
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