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>   home   >   Products   >   Primary Antibodies   >   Anti-Epstein-Barr Virus LMP2A Antibody, clone 15F9    

Anti-Epstein-Barr Virus LMP2A Antibody, clone 15F9

Rat Anti-Viral Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Virus
Host Rat
Clonality Monoclonal
Isotype IgG1
Clone Names 15F9
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Bacterial TrpE-LMP2A fusion protein.
Shelf Life 18 months from date of despatch.
Target/Specificity Rat anti-Epstein-Barr Virus LMP2A antibody, clone 15F9 recognizes latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV). EBV is a human herpesvirus, which is associated with conditions such as Hodgkin’s disease and Burkitt’s Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals. ABD11792 specifically recognizes LMP2A and does not cross react with LMP2B.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Epstein-Barr Virus LMP2A Antibody, clone 15F9 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Niedobitek, G. et al. (1997) Immunohistochemical detection of the Epstein-Barr virus-encoded latent membrane protein 2A in Hodgkin’s disease and infectious mononucleosis.
Blood. 90: 1664-1672. 2. Lung, R.W. et al. (2009) Modulation of LMP2A expression by a newly identified Epstein-Barr virus-encoded microRNA miR-BART22.
Neoplasia. 11: 1174-84. 3. Serafini, B. et al. (2010) Epstein-Barr virus latent infection and BAFF expression in B cells in the multiple sclerosis brain: implications for viral persistence and intrathecal B-cell activation.
J Neuropathol Exp Neurol. 69: 677-93. 4. Deshpande, C.G. et al. (2002) Lack of expression of the Epstein-Barr Virus (EBV) gene products, EBERs, EBNA1, LMP1, and LMP2A, in breast cancer cells.
Lab Invest. 82: 1193-9.

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Cat# ABD11792
(40 western blots)
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