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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Human MCP-1 Antibody, clone 2.2-4A4-1A11    

Anti-Human MCP-1 Antibody, clone 2.2-4A4-1A11

Mouse Anti-Human Monoclonal Antibody

     
  • IHC - Anti-Human MCP-1 Antibody, clone 2.2-4A4-1A11  ABD11795
    Formalin fixed, paraffin embedded human breast ductal carcinoma stained with Mouse anti Human MCP-1 following antigen retrieval with sodium citrate buffer (pH6.0)
  • IHC-P - Anti-Human MCP-1 Antibody, clone 2.2-4A4-1A11  ABD11795
    Formalin fixed, paraffin embedded human breast ductal carcinoma stained with Mouse anti Human MCP-1 following antigen retrieval with sodium citrate buffer (pH6.0)
  • E - Anti-Human MCP-1 Antibody, clone 2.2-4A4-1A11  ABD11795
    Sandwich ELISA analysis of human MCP-1 using Mouse anti Human MCP-1 as a capture reagent and biotinylated Rabbit anti Human MCP-1 as a detection reagent with recombinant human MCP-1 as antigen. Detection is by HRP conjugated streptavidin and substrate. Microtitre plate is read at O.D. 450 nm on the Bio-Rad iMark Microplate Absorbance Reader . Serum and plasma samples are included undiluted
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P13500
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 2.2-4A4-1A11
Calculated MW 11025 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Immunogen Recombinant human MCP-1/MCAF ( PHP061)
Shelf Life 12 months from date of reconstitution.
Gene ID 6347
Other Names C-C motif chemokine 2, HC11, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte chemotactic protein 1, MCP-1, Monocyte secretory protein JE, Small-inducible cytokine A2, CCL2, MCP1, SCYA2
Target/Specificity Mouse anti-Human MCP-1 antibody, clone 2.2-4A4-1A11 recognizes human C-C motif chemokine 2, also known as Monocyte chemoattractant protein 1 (MCP-1), Monocyte chemotactic and activating factor, Monocyte secretory protein JE, Small-inducible cytokine A2 or CCL2, and does not cross react with MCP-2, MCP-3 or other structurally related chemokines. MCP-1 is a 99 amino acid, including a 23 aa signal peptide ~13kDa chemotactic protein, a chemoattractant for monocytes and basophils but not neutrophils or eosinophils (Weberet al.1996).MCP-1 is produced by a number of cell types, including monocytes, macrophages, microglia, fibroblasts and epithelial cells (Cushinget al.1990). MCP-1 influences T-cell immunity polarizing responses towards the Th2 phenotype (Karpus and Kennedy 1997). Variations in the CCL2 gene affects susceptibility to Mycobacteriun tuberculosis infection (Flores-Villanuevaet al.2005).Mouse anti-Human MCP-1 antibody, clone 2.2-4A4-1A11 recognizes both native and recombinant MCP-1 in conjunction with Rabbit anti-Human MCP-1 polyclonal antibody in a sensitive sandwich ELISA assay.
Preservative & Stabilisers Preservative Free
Storage Storage at 4℃ or at -20℃.
PrecautionsAnti-Human MCP-1 Antibody, clone 2.2-4A4-1A11 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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References

1. Johansson, U. et al. (2008) Formation of composite endothelial cell-mesenchymal stem cell islets: a novel approach to promote islet revascularization.
Diabetes. 57: 2393-401. 2. Nio-Kobayashi J et al. (2015) Regulated C-C motif ligand 2 (CCL2) in luteal cells contributes to macrophage infiltration into the human corpus luteum during luteolysis.
Mol Hum Reprod. pii: gav028.

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Cat# ABD11795
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