|Application ||IHC-P, IHC-F, E|
|Calculated MW||23010 Da|
|Purification||Purified IgG prepared by affinity chromatography|
|Immunogen||Human Retinol Binding Protein purified from plasma|
|Shelf Life||18 months from date of despatch.|
|Other Names||Retinol-binding protein 4, Plasma retinol-binding protein, PRBP, RBP, Plasma retinol-binding protein(1-182), Plasma retinol-binding protein(1-181), Plasma retinol-binding protein(1-179), Plasma retinol-binding protein(1-176), RBP4|
|Target/Specificity||ABD11803 recognises an epitope within the 74-182 C-terminal (CT) sequence (11kD peptide fragment) of human serum Retinol Binding Protein (RBP), a single-chain glycoprotein belonging to the superfamily of hydrophobic molecule transporter proteins, which is responsible for the transport of Retinol (vitamin A1) from the liver to peripheral target tissues.RBP is synthesised by hepatic parenchymal cells where it becomes bound to its ligand retinol and is then released into the circulation, where it binds further to the protein transthyretin, to form a transporting complex. An increasing number of studies suggest that the subsequent release of retinol from RBP at the plasma membrane occurs through interaction of RBP with specific membrane receptors.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Retinol Binding Protein Antibody, clone G4E4 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Reddy, B.M. et al. (1993) Antigenic determinants of human serum retinol binding protein as probed with monoclonal antibodies. Mol. Immunol. 30: 1355-1360.1. Sundaram, M. et al. (1998) The transfer of retinol from serum retinol-binding protein to cellular retinol-binding protein is mediated by a membrane receptor*. J. Biol. Chem. 273: 3336-3342.
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