|Calculated MW||68986 Da|
|Other Species||Cynomolgus Pr|
|Immunogen||Spleen lymphocytes from mice fused with the ovcar-3 ovarian carcinoma cell line.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Mesothelin, CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, Megakaryocyte-potentiating factor, MPF, Mesothelin, cleaved form, MSLN, MPF|
|Target/Specificity||Mouse anti-Human Mesothelin, clone K1, recongnizes a 40kDa GPI-anchored cell surface glycoprotein also known as CAK1. Mesothelin is a differentiation antigen present on normal mesothelial cells and overexpressed in several human tumors, including mesothelioma; ovarian and pancreatic adenocarcinoma. Mesothelin is attached to the cell membrane by a glycosylphosphatidyl inositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF).Clone K1 antibody has been used to differentiate between epithelial malignant mesothelioma and lung adenocarcinomas by immunohistology.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Mesothelin Antibody, clone K1 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Scholler, N. et al. (1999) Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma.Proc Natl Acad Sci. 96:11531-6. 2. Hassan, R. et al. (2004) Mesothelin: a new target for immunotherapy. Clin Cancer Res. 10:3937-42.
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