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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human Tyrosinase Related Protein 1 Antibody, clone Ta99    

Anti-Human Tyrosinase Related Protein 1 Antibody, clone Ta99

Mouse Anti-Human Monoclonal Antibody

     
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  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-F
Primary Accession P17643
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names Ta99
Calculated MW 60724 Da
Additional Information
Immunogen SK-MEL-23 melanoma.
Shelf Life 18 months from date of despatch.
Gene ID 7306
Other Names 5, 6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase, 1.14.18.-, Catalase B, Glycoprotein 75, Melanoma antigen gp75, Tyrosinase-related protein 1, TRP, TRP-1, TRP1, TYRP1, CAS2, TYRP, TYRRP
Target/Specificity ABD11808 detects Tyrosinase-related protein-1 (TRP-1), a 75kDa melanocyte-specific gene product involved in eumelanin synthesis which is present on the melanosomal membrane of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintanence of melanosome ultrastructure and affects melanocyte proliferation and cell death. Defects in TRP-1 affect pigmentation in melanosomes, and have been shown to cause two diseases dependent on skin colour; rufous oculocutaneous albinism (ROCA) occurs predominantly in southern African blacks and oculocutaneous albinism type III (OCA-III/3) a form of albinism with only moderate reduction of pigment.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Tyrosinase Related Protein 1 Antibody, clone Ta99 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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References

1. Thomson, T.M. et al. (1985) Pigmentation-associated glycoprotein of human melanomas and melanocytes:definition with a mouse monoclonal antibody.
J Invest Dermatol. 85: 169 - 74. 2. Welt, S. et al. (1987) Monoclonal antibody to an intracellular antigen images human melanoma transplantsin nu/nu mice.
Proc Natl Acad Sci U S A. 84:4200 - 4204. 3. Sarangarajan, R. and Boissy, R.E. (2001) Tyrp1 and oculocutaneous albinism type 3.
Pigment Cell Res. 14: 437-444. 4. del Marmol, V. and Beermann, F. (1996) Tyrosinase and related proteins in mammalian pigmentation.
FEBS Lett. 381: 165-168.

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Cat# ABD11808
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