|Calculated MW||60724 Da|
|Shelf Life||18 months from date of despatch.|
|Other Names||5, 6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase, 1.14.18.-, Catalase B, Glycoprotein 75, Melanoma antigen gp75, Tyrosinase-related protein 1, TRP, TRP-1, TRP1, TYRP1, CAS2, TYRP, TYRRP|
|Target/Specificity||ABD11808 detects Tyrosinase-related protein-1 (TRP-1), a 75kDa melanocyte-specific gene product involved in eumelanin synthesis which is present on the melanosomal membrane of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintanence of melanosome ultrastructure and affects melanocyte proliferation and cell death. Defects in TRP-1 affect pigmentation in melanosomes, and have been shown to cause two diseases dependent on skin colour; rufous oculocutaneous albinism (ROCA) occurs predominantly in southern African blacks and oculocutaneous albinism type III (OCA-III/3) a form of albinism with only moderate reduction of pigment.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Tyrosinase Related Protein 1 Antibody, clone Ta99 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Thomson, T.M. et al. (1985) Pigmentation-associated glycoprotein of human melanomas and melanocytes:definition with a mouse monoclonal antibody.J Invest Dermatol. 85: 169 - 74. 2. Welt, S. et al. (1987) Monoclonal antibody to an intracellular antigen images human melanoma transplantsin nu/nu mice.Proc Natl Acad Sci U S A. 84:4200 - 4204. 3. Sarangarajan, R. and Boissy, R.E. (2001) Tyrp1 and oculocutaneous albinism type 3. Pigment Cell Res. 14: 437-444. 4. del Marmol, V. and Beermann, F. (1996) Tyrosinase and related proteins in mammalian pigmentation. FEBS Lett. 381: 165-168.
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