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>   home   >   Products   >   Primary Antibodies   >   Anti-Feline Leukaemia Virus p15E Antibody, clone PF6J-2A1    

Anti-Feline Leukaemia Virus p15E Antibody, clone PF6J-2A1

Mouse Anti-Viral Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Virus
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names PF6J-2A1
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Shelf Life 18 months from date of despatch.
Target/Specificity Mouse anti-Feline leukemia virus p15e antibody, clone PF6J-2A1 recognizes an epitope within the amino-terminal domain of both the 20 kDa full-length (including intracellular sequence), and the 15k Da truncated forms, of feline leukaemia virus (FeLV) p15e transmembrane envelope protein.Persistent infection of cats with the oncoretrovirus FeLV can result in the non-neoplastic condition known as FeLV-associated enteritis (FAE). Studies have shown strong expression of the major FeLV proteins p15e and gp70 in intestinal crypt epithelial cells of cats with FAE, compared to FeLV-positive cats without intestinal alterations, thereby suggesting a pathogenic role for these envelope proteins/precursors in FAE.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Feline Leukaemia Virus p15E Antibody, clone PF6J-2A1 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Kipar, A. et al. (2000) Expression of viral proteins in feline leukemia virus-associated enteritis.
Vet. Pathol. 37: 129-136. 2. Kipar, A. et al. (2001) Comparative examination of cats with feline leukemia virus-associated enteritis and other relevant forms of feline enteritis.
Vet. Pathol. 38: 359-371. 3. Burns, C.C. et al. (1995) Mutations within a putative cysteine loop of the transmembrane protein of an attenuated immunodeficiency-inducing feline leukemia virus variant inhibit envelope protein processing.
J. Virol. 69: 2126-2132. 4. Gwynn, S.R. et al. (2000) Feline leukemia virus envelope sequences that affect T-cell tropism and syncytium formation are not part of known receptor-binding domains.
J. Virol. 74: 5754-5761. 5. Argaw, T. & Wilson,A. (2015) Mutations altering the gammaretrovirus endoproteolytic motif affect glycosylation of the envelope glycoprotein and early events of the virus life cycle.
Virology. 475: 110-9.

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Cat# ABD11809
(40 western blots)
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