|Calculated MW||308056 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Immunogen||Clostridium difficile toxin A.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Toxin A, toxA, tcdA|
|Target/Specificity||ABD11824 is specific for Clostridium difficile toxin A. No reaction is observed with the following organisms:Clostridium difficile toxin B, tetanus toxoid, Pseudomonas aeruginosaandYersinia enterocoliticaClostridium difficile isa gram-positive motile bacterium which is the leading cause of diarrhoea in developed countries. The incidence of disease in humans varies greatly with age, spore density and the administration of antibiotics. Toxin A (TcdA) is a large exotoxin which is an essential virulence factor for C. difficile infection. TcdA has a molecular weight of 308kD and is a glucosyltransferase, which irreversibly inactivates the Ras family of small GTPases to disrupt many important signalling pathways.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Clostridium difficile Toxin A Antibody, clone 5157 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Voth, D.E. and Ballard, J.D. (2005) Clostridium difficile toxins: mechanism of action and role in disease. Clin. Microbiol. Rev. 18: 247-263.
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