Anti-Human C3d Antibody, clone 053A-1188.8.131.52 (also known as 1003)
Mouse Anti-Human Monoclonal Antibody
|Application ||WB, IHC-F, FC, E|
|Clone Names||053A-1184.108.40.206 (also known as 1003)|
|Calculated MW||187148 Da|
|Purification||Purified Ig prepared by affinity chromatography on Protein A.|
|Immunogen||Purified C3d from human plasma.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, Complement C3 beta chain, C3-beta-c, C3bc, Complement C3 alpha chain, C3a anaphylatoxin, Acylation stimulating protein, ASP, C3adesArg, Complement C3b alpha' chain, Complement C3c alpha' chain fragment 1, Complement C3dg fragment, Complement C3g fragment, Complement C3d fragment, Complement C3f fragment, Complement C3c alpha' chain fragment 2, C3, CPAMD1|
|Target/Specificity||Mouse anti-Human C3d antibody, clone 053A-1220.127.116.11 recognizeshuman complement component 3d (C3d), a 33kDa polypeptide fragment generated over the course of complement activation where complement 3 (C3) convertases cleave C3 to C3b, which is further degraded into iC3b and C3dg/C3d. C3d is involved in the regulation of many aspects of the immune response, including antigen processing and presentation. The C3d/antigen complex mediates B cell activation by simultaneously binding antigen-specific surface bound immunoglobulin and CD21, lowering the complement activation threshold. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human C3d Antibody, clone 053A-118.104.22.168 (also known as 1003) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Gay, F. (2013) Staphylococcal immune complexes and myelinolytic toxin in early acute multiple sclerosis lesions-An immunohistological study supported by multifactorial cluster analysis and antigen-imprint isoelectric focusing.Mult Scler Relat Disord. 2 (3): 213-32.1. Bergmann-Leitner, E.S. et al. (2006) Complement 3d: from molecular adjuvant to target of immune escape mechanisms.Clin Immunol. 121 (2): 177-85.
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