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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human C4c Antibody, clone 10-12    

Anti-Human C4c Antibody, clone 10-12

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P0C0L5
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 10-12
Calculated MW 192751 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Purified human C4c.
Shelf Life 18 months from date of despatch.
Gene ID 100293534;721
Other Names Complement C4-B, Basic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, Complement C4 beta chain, Complement C4-B alpha chain, C4a anaphylatoxin, C4b-B, C4d-B, Complement C4 gamma chain, C4B, CO4, CPAMD3
Target/Specificity Mouse anti-Human C4c antibody, clone 10-12 recognizes complement component 4c (C4c). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b’s alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. iC4b is further degraded into the inactive fragments C4d and C4c. C4c consists of two a-chain fragments, alpha 4 (13 kDa) and alpha 3 (25 kDa) linked to a beta chain through disulphide bridges and a gamma chain. It is expressed in the blood plasma.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human C4c Antibody, clone 10-12 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Leung, E. et al. (2006) The complement regulator C4b-binding protein (C4BP) interacts with both the C4c and C4dg subfragments of the parent C4b ligand: evidence for synergy in C4BP subsite binding.
Biochemistry. 45: 8378-8392.

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Cat# ABD11831
(40 western blots)
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