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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human C4bp Antibody, clone 10-07    

Anti-Human C4bp Antibody, clone 10-07

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P04003
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 10-07
Calculated MW 67033 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Native human C4 binding protein.
Shelf Life 18 months from date of despatch.
Gene ID 722
Other Names C4b-binding protein alpha chain, C4bp, Proline-rich protein, PRP, C4BPA, C4BP
Target/Specificity Mouse anti-human C4bp monoclonal antibody, clone 10-07, recognizes complement component 4 binding protein (C4bp). There are three variants of C4bp, composed of alpha and beta chains. The predominant form is a 570 kDa complex of 7 alpha chains and 1 beta chain. The other complexes formed are a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain.C4bp regulates the activation of the classical complement pathway. It is a cofactor to the C3b/C4b inactivator, crucial to the proteolytic cleavage of C4b and important in cleavage of C3b. C4bp also regulates the C4bC2a complex (C3 convertase), accelerating its degradation by dissociating the complement fragment C2a. Both the C4bp alpha and beta chains interact with anticoagulant protein S and C4bp alpha binds protein S. C4bp is expressed in the blood serum.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human C4bp Antibody, clone 10-07 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Huang Shan et al. (2016) Reciprocal relationship between contact and complement system activation on artificial polymers exposed to whole human blood
Biomaterials. 77: 111-119.1. Blom, A.M. et al. (2004) Functions of human complement inhibitor C4b-binding protein in relation to its structure.
Arch Immunol Ther Exp (Warsz). 52 (2): 83-95.

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Cat# ABD11832
(40 western blots)
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