|Calculated MW||67033 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Native human C4 binding protein.|
|Shelf Life||18 months from date of despatch.|
|Other Names||C4b-binding protein alpha chain, C4bp, Proline-rich protein, PRP, C4BPA, C4BP|
|Target/Specificity||Mouse anti-human C4bp monoclonal antibody, clone 10-07, recognizes complement component 4 binding protein (C4bp). There are three variants of C4bp, composed of alpha and beta chains. The predominant form is a 570 kDa complex of 7 alpha chains and 1 beta chain. The other complexes formed are a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain.C4bp regulates the activation of the classical complement pathway. It is a cofactor to the C3b/C4b inactivator, crucial to the proteolytic cleavage of C4b and important in cleavage of C3b. C4bp also regulates the C4bC2a complex (C3 convertase), accelerating its degradation by dissociating the complement fragment C2a. Both the C4bp alpha and beta chains interact with anticoagulant protein S and C4bp alpha binds protein S. C4bp is expressed in the blood serum.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human C4bp Antibody, clone 10-07 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Huang Shan et al. (2016) Reciprocal relationship between contact and complement system activation on artificial polymers exposed to whole human bloodBiomaterials. 77: 111-119.1. Blom, A.M. et al. (2004) Functions of human complement inhibitor C4b-binding protein in relation to its structure.Arch Immunol Ther Exp (Warsz). 52 (2): 83-95.
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