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>   home   >   Products   >   Primary Antibodies   >   Anti-Human SC5b-9 Antibody, clone 3R2/0    

Anti-Human SC5b-9 Antibody, clone 3R2/0

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 3R2/0
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Shelf Life 18 months from date of despatch.
Target/Specificity Mouse anti-Human SC5b-9 antibody, clone 3R2/0 recognizes the SC5b-9 complex of around 330 kDa. Both the classical and alternative complement pathways result in the formation of the cytolysis inducing C5b-9 complex. This complex is composed of 190 kDa C5b which is bound to cells via 71 kDa C9. Sublytic assembly of C5b-9 on plasma membranes induces cell cycle activation and survival. The binding of C5b-9 to the 75 kDa S-protein (or vitronectin) in the fluid phase prevents C5b-9 from assembling on the plasma membrane, deactivating it and forming the SC5b-9 complex. SC5b-9 is stable in vitro and is therefore a reliable indicator of terminal complement pathway activation.Removal of Sodium Azide is recommended prior to use in functional assays. AbD Serotec recommend the use of EQU003 for this purpose. Mouse anti-Human SC5b-9 antibody, clone 3R2/0 has been reprted to work in western blotting applications.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human SC5b-9 Antibody, clone 3R2/0 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Biesecker, G. (1990) The complement SC5b-9 complex mediates cell adhesion through a vitronectin receptor.
J. Immunol. 145:209. 2. Greenstein, J. et al. (1995) The kinetics and distribution of C9 and SC5b-9 in vivo: effects of complement activation.
Clin. Exp. Immunol.100:40-6. 3. Rus H, et al. (2005) C5b-9 complement complex in autoimmune demyelination and multiple sclerosis: dual role in neuroinflammation and neuroprotection.
Ann Med. 37:97-104.

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Cat# ABD11834
(40 western blots)
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