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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human Clusterin Antibody, clone 3R3/2    

Anti-Human Clusterin Antibody, clone 3R3/2

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10909
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 3R3/2
Calculated MW 52495 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Glomerular basement membrane from a post-mortem kidney.
Shelf Life 18 months from date of despatch.
Gene ID 1191
Other Names Clusterin, Aging-associated gene 4 protein, Apolipoprotein J, Apo-J, Complement cytolysis inhibitor, CLI, Complement-associated protein SP-40, 40, Ku70-binding protein 1, NA1/NA2, Testosterone-repressed prostate message 2, TRPM-2, Clusterin beta chain, ApoJalpha, Complement cytolysis inhibitor a chain, Clusterin alpha chain, ApoJbeta, Complement cytolysis inhibitor b chain, CLU, APOJ, CLI, KUB1
Target/Specificity ABD11835 recognises clusterin, an ubiquitously expressed protein of two 40-kD chains, alpha and beta, covalently joined by disulfide bonds. It exists in two forms; a pro-apoptotic form localised to the nucleus and a pro-survival secreted form.Both are thought to be involved in DNA repair and cell cycle regulation. The secreted form is thought to inhibit apoptotic signalling by BAX, Clusterin suppression can sensitise cells to chemotherapy. Clusterin is overexpressed in human prostate cancer, breast cancers and squamous cell carcinomas. Part of the SC5b-9 complex, clusterin prevents the binding of a C5b-C7 complex to the membrane of the target cell inhibiting the complement cascade. Clusterin acts as an extracellular chaperone inhibiting the formation of human lysozyme amyloid associated with Alzheimer’s disease. Clusterin is also important in spermatogenesis and is secreted by Sertoli cells.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Clusterin Antibody, clone 3R3/2 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Kumita, J. et al. (2007) The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.
J. Mol. Biol. 369:157-167. 2. Shannan, B. et al. (2006) Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control.
J. Mol. Histol. 37:183-188.

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Cat# ABD11835
(40 western blots)
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